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Data Presented at Society for Neuro-Oncology Annual Meeting Demonstrate Tocagen's Toca 511 Gene Therapy with Toca FC was Well Tolerated and Showed Antitumor Activity in Patients with High Grade Glioma
Date:11/26/2013

nti-cancer drug 5-fluorouracil (5-FU). By producing 5-FU locally with CD, this technology has the potential to produce much higher intratumoral concentrations of 5-FU than can be currently attained with systemic administration. In these studies, patients receive a single administration of Toca 511 at the time of surgical removal of the brain tumor or by transcranial injection into the tumor followed by repeat cycles of oral Toca FC. A study in patients with brain cancer has recently been initiated to evaluate intravenous administration of Toca 511 followed by oral Toca FC.

About Tocagen

Tocagen Inc. is a privately funded, clinical stage biopharmaceutical company pursuing the discovery, development and commercialization of gene therapy products for the treatment of cancer. Tocagen is initially focusing on treatments for patients with advanced cancer for whom no adequate treatments currently exist. Toca 511 and Toca FC, the company's lead investigational combination product, is being evaluated in three clinical trials in patients with recurrent high grade glioma, including glioblastoma multiforme (GBM). Tocagen has received grant support from leading brain cancer foundations, including Accelerate Brain Cancer Cure (ABC2), National Brain Tumor Society (NBTS), American Brain Tumor Association (ABTA), Musella Foundation and Voices Against Brain Cancer (VABC). For more information about Tocagen or Toca 511 please visit www.tocagen.com or www.clinicaltrials.gov.


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