Navigation Links
Data Presented at Society for Neuro-Oncology Annual Meeting Demonstrate Tocagen's Toca 511 Gene Therapy with Toca FC was Well Tolerated and Showed Antitumor Activity in Patients with High Grade Glioma
Date:11/26/2013

groups. Since radiation therapy and temozolomide are part of standard therapy for patients with newly diagnosed GBM, these data provide support for clinical investigation of Toca 511 and Toca FC in first line therapy.

"I am pleased with the progress we have made with our clinical programs, and the available survival data provide optimism for subsequent dose groups in these studies," said Harry Gruber, M.D., CEO of Tocagen. "The results from our ongoing clinical studies, taken together with the depth of our preclinical research, provide momentum for the continued investigation of this novel gene therapy for patients with brain cancer."

Data from preclinical brain cancer studies also presented at the conference demonstrate the feasibility of intravenous administration of Toca 511 as a potential complement to the current intra-tumoral delivery methods. An investigational trial was recently initiated to evaluate intravenous delivery of Toca 511 in combination with courses of oral Toca FC in patients with recurrent HGG (NCT01985256). In the future, Toca 511 may be investigated for the treatment of additional types of cancers beyond brain cancer, including metastatic cancers.

About Toca 511 and Toca FC

The combination of Toca 511 (vocimagene amiretrorepvec) for injection and Toca FC (flucytosine) extended-release tablets, is being investigated in Phase I studies at leading centers across the United States in patients with recurrent high grade glioma, including glioblastoma multiforme (GBM). Toca 511 is a retroviral replicating vector (RRV) that is designed to deliver a prodrug activator gene called cytosine deaminase (CD) selectively to cancer cells. After allowing time for Toca 511 to spread through the tumor, those cancer cells expressing the CD gene can convert the antibiotic drug flucytosine into the a
'/>"/>

SOURCE Tocagen Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Latest Findings in Breastfeeding Science Presented at Medelas 7th International Breastfeeding and Lactation Symposium
2. Interim results of VITOBA™ (VImpaT® added to One Baseline AED) Study Presented at the 64th Annual Meeting of the American Academy of Neurology
3. Worldwide Multicenter Experiences with CardioFocus HeartLight® EAS to be Presented at Heart Rhythm 2012
4. Data Presented at the American Psychiatric Association Annual Meeting Supports Gender-Specific Dosing of Intermezzo® (zolpidem tartrate) Sublingual Tablets CIV
5. New Data to be Presented at the Annual American Thoracic Society International Conference Demonstrates Depth of Boehringer Ingelheim Respiratory Research Pipeline
6. eCardios CEO to Speak During "Act at the Speed of Opportunity" Event Presented by Comcast Business Class and Inc.
7. CutisPharma Homogeneity and Stability Study for Mouthwash Compounding Kits Presented at NERDG Meeting
8. Results of Phase II Study of Boehringer Ingelheims Investigational Bronchodilator for COPD Presented at 2012 ATS International Conference
9. Webcast Alert: Isis Pharmaceuticals Hosts Dr. Sotirios Tsimikas to Review KYNAMRO™ data Presented at the European Atherosclerosis Society 2012 Meeting
10. Body Monitors Deliver Better Weight Loss Results at Half the Cost: Study to Be Presented at ACSM Meeting
11. CyberKnife® Prostate SBRT Outcomes and Quality of Life Data Presented at American Urological Association Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... , Sept. 15, 2014 /PRNewswire-iReach/ -- MedicOne Medical Response, ... services, has been selected by Inc. Magazine as ... America. Photo - http://photos.prnewswire.com/prnh/20140914/145997 ... list identifies successful, privately-held companies with the largest ... Response, one of only two ambulance companies to ...
(Date:9/15/2014)... /PRNewswire-iReach/ -- CaPtivate Pharmaceuticals LLC, a ... (CaP)-based nanoparticle drug and vaccine delivery technologies, announced ... Agreement with Immunotope Inc., another Pennsylvania ... the treatment and prevention of viral infections and ... the agreement, Immunotope is granted a non-exclusive world-wide ...
(Date:9/15/2014)... The Society of Corporate Compliance and ... than 4,500 compliance and ethics professionals from across ... corporate fines and settlements.  The SCALENDAR is designed ... ready reference to demonstrate to employees the consequences ... to help compliance and ethics officers looking for ...
Breaking Medicine Technology:MedicOne Medical Response Named to 2014 Inc. 5000 Fastest Growing Companies List 2MedicOne Medical Response Named to 2014 Inc. 5000 Fastest Growing Companies List 3CaPtivate Pharmaceuticals Enters License Agreement With Immunotope 2CaPtivate Pharmaceuticals Enters License Agreement With Immunotope 3More than $55 billion in fines and settlements added by SCCE to its 2015 Corporate Scandal Calendar 2
... , WAYNE, N.J. and EMERYVILLE, Calif., Dec. ... Inc. (Nasdaq: ONXX ) today announced results ... 2 trials were presented at the 32nd Annual ... of these studies evaluated Nexavar® (sorafenib) tablets in ...
... , BATESVILLE, Ind., Dec. 11 Hill-Rom (NYSE: ... use in medical-surgical areas of hospitals and care facilities. The new bed ... to use a variety of care surfaces as needed. , "Hill-Rom ... the best features of Hill-Rom,s long-time leader, the Advanta bed, with many ...
Cached Medicine Technology:Nexavar in Combination With Chemotherapy Demonstrates Activity in Patients With Advanced Breast Cancer in Two Phase 2 Studies 2Nexavar in Combination With Chemotherapy Demonstrates Activity in Patients With Advanced Breast Cancer in Two Phase 2 Studies 3Nexavar in Combination With Chemotherapy Demonstrates Activity in Patients With Advanced Breast Cancer in Two Phase 2 Studies 4Nexavar in Combination With Chemotherapy Demonstrates Activity in Patients With Advanced Breast Cancer in Two Phase 2 Studies 5Nexavar in Combination With Chemotherapy Demonstrates Activity in Patients With Advanced Breast Cancer in Two Phase 2 Studies 6Nexavar in Combination With Chemotherapy Demonstrates Activity in Patients With Advanced Breast Cancer in Two Phase 2 Studies 7Hill-Rom Introduces Innovative Smart Bed for Medical-Surgical Settings 2Hill-Rom Introduces Innovative Smart Bed for Medical-Surgical Settings 3Hill-Rom Introduces Innovative Smart Bed for Medical-Surgical Settings 4
(Date:9/16/2014)... (PRWEB) September 16, 2014 ... information media site, launches their new site today. ... additional features aimed at making information easier to ... sift, we distill into one-page, easy-to-read pages the ... should know!” says Virginia Downie, retired college professor ...
(Date:9/16/2014)... 2014 The Living Ethics lecture series ... Reflecting on what it means to live in an ... unique and thought-provoking topics. , “The Museum’s job is ... look at their world differently. The Living Ethics ... for truly enlightening dialogue,” says Richard Conti, Chief Wonder ...
(Date:9/16/2014)... Banish headaches forever with the newest ... device for chronic migraine relief and treatment. Cefaly was ... States. Until now, US patients would directly place their ... and wait 2-3 weeks for their device to arrive. ... and once prescription and payment is received, the Cefaly ...
(Date:9/16/2014)... Recently, BamboofloorChina.com, a famous online supplier of bamboo products, ... bamboo panels . The firm is now offering ... its high quality items. Please note that the big ... 2014. , According to the company’s chief executive ... should visit BamboofloorChina.com before September 28. BamboofloorChina.com is offering ...
(Date:9/15/2014)... 16, 2014 Career Step, an ... training, is pleased to announce that Panacea Healthcare ... PCS comprehensive skill assessments and the ICD-10-CM and ... and Panacea’s consulting division. , “We are excited ... ICD-10 to our clients,” said Suzanne Lappen, Panacea ...
Breaking Medicine News(10 mins):Health News:JustThoughtYouShouldKnow.org Debuts New Website 2Health News:Expanding Community Vision at the Science Museum of Virginia 2Health News:Cefaly Migraine Treatment Device Now Readily Available For Widespread Purchase in United States 2Health News:Cheap Bamboo Panels Unveiled By Famous Online Supplier BamboofloorChina.com 2Health News:Panacea Healthcare Solutions to Resell Career Step’s ICD-10-CM and PCS Assessments and Case Studies 2Health News:Panacea Healthcare Solutions to Resell Career Step’s ICD-10-CM and PCS Assessments and Case Studies 3
... more attention be paid after hospital discharge, , , MONDAY, ... the veterans treated in Veterans Affairs hospitals suffer from ... suicide than non-depressed veterans, University of Michigan researchers report. ... and might it be related to their use of ...
... conjunction with its fourth quarter 2008 earnings release (expected to be issued after ... is pleased to invite you to listen to its quarterly investor conference call ... at 9:00 a.m. ET., What: Covance Fourth ... Presentation, When: ...
... Outdoor Recreation Participation StudyFindings include increase in overall ... The Outdoor Foundation today announced the ... Report, the only detailed study of its ... The findings highlighted in the report are areas ...
... Club is hosting a,Pharmacy Challenge and Savings Checkup in ... check prices on their prescriptions and,over-the-counter medications against other ... on branded prescriptions. Membership is not,required to use ... "Your Healthy Year" promotes a variety of ways consumers ...
... FRANCISCO, Jan. 12 Within health care, dermatology,professionals play ... , The Dermatology Nurses, Association ... practice in a variety,of learning formats and the opportunity ... annual conference slated for March,4-7 at the Hilton San ...
... CYBX ) today announced that Milton ... Research and Development, effective on January 12, 2009. ... company,s development programs. Dr. Morris joins Cyberonics from ... company in North Carolina, where he has served ...
Cached Medicine News:Health News:With Depression, Vets Face Higher Suicide Risk 2Health News:With Depression, Vets Face Higher Suicide Risk 3Health News:As Childhood Obesity Rates Rise, Youth Outdoor Participation Declines 2Health News:As Childhood Obesity Rates Rise, Youth Outdoor Participation Declines 3Health News:Sam's Club(R) Hosts Pharmacy Challenge 2Health News:Hop the Trolley for DNA's 27th Annual Conference 2Health News:Cyberonics Names Milton M. Morris, Ph.D. Vice President, Research & Development 2Health News:Cyberonics Names Milton M. Morris, Ph.D. Vice President, Research & Development 3Health News:Cyberonics Names Milton M. Morris, Ph.D. Vice President, Research & Development 4
Optipress II Automated Blood Component Extractor for the standardized separation of whole blood into high purity individual components...
The Eppendorf Maxipettor is a continuously adjustable pipette for precise pipetting of volumes up to 10 ml (in 10 l increments). Even liquids with a high vapor pressure or viscosity can be pipetted w...
eValuator fixed-curve diagnostic electrophysiology catheters offer an effective balance between clinical performance and cost....
... Two high performance technologies - Quantum™ ... shaft platform - unite in the ... a high dilatation force balloon with ... Laser bonded Maverick® shaft technology improves ...
Medicine Products: