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Data Presented at Society for Neuro-Oncology Annual Meeting Demonstrate Tocagen's Toca 511 Gene Therapy with Toca FC was Well Tolerated and Showed Antitumor Activity in Patients with High Grade Glioma
Date:11/26/2013

groups. Since radiation therapy and temozolomide are part of standard therapy for patients with newly diagnosed GBM, these data provide support for clinical investigation of Toca 511 and Toca FC in first line therapy.

"I am pleased with the progress we have made with our clinical programs, and the available survival data provide optimism for subsequent dose groups in these studies," said Harry Gruber, M.D., CEO of Tocagen. "The results from our ongoing clinical studies, taken together with the depth of our preclinical research, provide momentum for the continued investigation of this novel gene therapy for patients with brain cancer."

Data from preclinical brain cancer studies also presented at the conference demonstrate the feasibility of intravenous administration of Toca 511 as a potential complement to the current intra-tumoral delivery methods. An investigational trial was recently initiated to evaluate intravenous delivery of Toca 511 in combination with courses of oral Toca FC in patients with recurrent HGG (NCT01985256). In the future, Toca 511 may be investigated for the treatment of additional types of cancers beyond brain cancer, including metastatic cancers.

About Toca 511 and Toca FC

The combination of Toca 511 (vocimagene amiretrorepvec) for injection and Toca FC (flucytosine) extended-release tablets, is being investigated in Phase I studies at leading centers across the United States in patients with recurrent high grade glioma, including glioblastoma multiforme (GBM). Toca 511 is a retroviral replicating vector (RRV) that is designed to deliver a prodrug activator gene called cytosine deaminase (CD) selectively to cancer cells. After allowing time for Toca 511 to spread through the tumor, those cancer cells expressing the CD gene can convert the antibiotic drug flucytosine into the a
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SOURCE Tocagen Inc.
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