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Data Presented at Society for Neuro-Oncology Annual Meeting Demonstrate Tocagen's Toca 511 Gene Therapy with Toca FC was Well Tolerated and Showed Antitumor Activity in Patients with High Grade Glioma
Date:11/26/2013

SAN DIEGO, Nov. 26, 2013 /PRNewswire/ -- Tocagen Inc. today announced that interim clinical data from two ongoing Phase I investigational studies presented at the Society for Neuro-Oncology (SNO) Annual Meeting in San Francisco showed that Toca 511 administration followed by courses of oral Toca FC was safe and well tolerated in 60 patients treated to date with recurrent high grade glioma (HGG). HGG includes glioblastoma multiforme (GBM), the most common and aggressive form of primary brain cancer. In addition, data were presented showing that in tumor samples taken from some patients following treatment, Toca 511 selectively infected tumor cells and expressed a cytosine deaminase (CD) transgene. Tumor necrosis (cell death) was also observed by microscopic examination.

In addition to safety and tolerability data, Timothy Cloughesy, M.D., director of the Neuro-Oncology Program at the University California, Los Angeles Jonsson Cancer Center and a principal investigator for the Toca 511 and Toca FC studies also presented evidence of antitumor activity and symptomatic improvement in some patients.

Toca 511 is a retroviral replicating vector that carries a gene for an enzyme that converts orally delivered Toca FC (extended-release 5-FC) into 5-FU, a potent anti-cancer agent. More information about the trials can be found at ClinicalTrials.gov using the identifiers NCT01470794 and NCT01156584.

In addition, posters were presented at the conference on Toca 511 and 5-FC in combination with temozolomide (TMZ) or radiation in preclinical glioma models, which showed significantly prolonged survival compared to control
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SOURCE Tocagen Inc.
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