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Data Presented at DDW About Rebound Symptoms in Healed Erosive Esophagitis Patients After Completion of Treatment with DEXILANT(TM) (dexlansoprazole)
Date:5/5/2010

NEW ORLEANS, May 5 /PRNewswire/ --

What:

Data results from a recent retrospective analysis of DEXILANT delayed release capsules and lansoprazole were presented at Digestive Disease Week (DDW) 2010 in New Orleans. DEXILANT is a proton pump inhibitor (PPI) with a Dual Delayed Release™ (DDR) formulation. Takeda recently announced that the product trade name for dexlansoprazole in the United States would be changed to DEXILANT from KAPIDEX™ (dexlansoprazole).

The medical community has been investigating whether patients who discontinue PPI therapy experience rebound gastric hypersecretion, and whether acid rebound is clinically relevant. Rebound acid hypersecretion is defined as an increase in gastric acid secretion above pretreatment levels following discontinuation of antisecretory therapy.

A new retrospective analysis of data from pivotal erosive esophagitis (EE) healing and maintenance of healed EE trials of H pylori-negative patients healed at Week 4 or 8:

  • Compared baseline and follow-up serum gastrin levels, a surrogate of acid hypersecretion, and 24-hour heartburn severity prior to enrolling patients in the EE healing trials with DEXILANT and lansoprazole, and then again after patients received placebo in the maintenance of healed EE trials.
  • Mean serum gastrin values at month 1 (N=130) and month 3 (N=52) after randomization to placebo in the maintenance trials were essentially unchanged versus baseline prior to the healing EE trials (N=216). Findings suggested that serum gastrin levels were normalized within 1 month of discontinuing PPIs and remained flat.
  • Mean heartburn severit
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SOURCE Takeda Pharmaceuticals North America, Inc.
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