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Data Presented at Annual Meeting of Japanese Society of Interventional Cardiology Demonstrate OrbusNeich's Genous(TM) Bio-engineered R Stent(TM) Has Better Outcomes When Compared to Drug-Eluting Stents
Date:7/7/2008

HONG KONG, July 7 /PRNewswire/ -- OrbusNeich today announced that data presented recently at the 17th Annual Meeting of the Japanese Society of Interventional Cardiology demonstrate that the Genous Bio-engineered R stent has better outcomes when compared to drug-eluting stents.

Presented by Federico Piscione, M.D., the study's principal investigator and a professor with the Federico II University of Naples's Division of Cardiology, Department of Clinical Medicine and Cardiovascular Sciences, the data were generated following a study that involved 257 consecutive high-risk patients who underwent percutaneous coronary intervention with either the Genous stent or a TAXUS(R) and CYPHER(R) stent at the university's catheterization lab.

At 13 months clinical follow-up, the cumulative MACE rate for the Genous (GRS) group was 17.2% versus 26.4% for the combined TAXUS and CYPHER group (DES), a 35% reduction. For the MACE components, the rate of myocardial infarction (MI) was 4.5% for GRS versus 6.8% for DES, the re-percutaneous coronary intervention (Re-PCI) was 7.5% for GRS and 13.5% for DES, and the cardiac death rate was 4.5% for GRS versus 7.4% for DES. In addition, the rate for stent thrombosis was 0% for GRS versus 5.8% for DES.

"Our results suggest that the Genous Bio-engineered R stent is safe and effective in high-risk patients," said Piscione. "The results show a better long-term clinical outcome when compared with DES."

After PCI, patients who received GRS were prescribed dual-antiplatelet therapy for one month, and patients who received DES were prescribed the same therapy for 12 months. A complete clinical follow-up was obtained in 100% of GRS patients vs. 96% of DES patients.

Additionally, 22 consecutive patients requiring "life saving", undeferrable major noncardiac surgery (NCS) or endovascular aortic repair (EVAR), underwent coronary angiography for clinical or instrumental signs of ischemia before NCS or EVAR and we
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