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Data Presented For ENMD-2076 In Xenograft Models Of Human Hepatocellular Carcinoma
Date:10/22/2013

ROCKVILLE, Md., Oct. 22, 2013 /PRNewswire/ -- EntreMed, Inc. (NASDAQ: ENMD), a clinical-stage pharmaceutical company developing therapeutics for the treatment of a variety of cancers, announced today the presentation of preclinical data for a study comparing the efficacy of ENMD-2076 against that of standard of care agents including sorafenib, doxorubicin, and 5-FU for human hepatocellular carcinoma (HCC) models.  The results of the study were presented at AACR-NCI-EORTC International Conference being held this week in Boston, Massachusetts.

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The data presented demonstrate significant in vivo activity of ENMD-2076 against three different human hepatocellular carcinoma xenograft models and concluded that ENMD-2076 showed robust antitumor activity against the cell line-derived xenograft models of human HCC superior to that of sorafenib, doxorubicin, and 5-FU.

Ken K. Ren, Ph.D., EntreMed's Chief Executive Officer, commented, "HCC represents the third leading cause of cancer deaths worldwide.  There are unmet medical needs for drugs with better safety and efficacy.  This in vivo preclinical study data is affirmative with our previous in vitro findings that greater than 60% of 21 liver cancer-derived cell lines we screened are significantly inhibited by ENMD-2076 treatment.  It also indicates that ENMD-2076 may be effective in patients resistant to sorafenib or 5-FU.  In our Phase 1 trial of ENMD-2076, partial response with prolonged progression free survival was observed in a patient with liver cancer who relapsed from standard care including liver transplantation and sorafenib treatment. This preclinical study provides support for further clinical investigation of the drug candidate in
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