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Data From Three Clinical Studies of bioTheranostics' Breast Cancer Molecular Test Presented at CTRC-AACR San Antonio Breast Cancer Symposium
Date:12/12/2009

nt," said Dr. Stal. "What is most important for us clinically is that the patients categorized by the BCI assay as 'low risk' had less than 4 percent chance of recurrence after 10 years." The ability to identify these low risk patients, who otherwise have pathological presentation similar to high risk patients, could significantly reduce the need for unnecessarily aggressive treatment in individual patients.

On Saturday, December 12, Laurie Habel, PhD, of Kaiser Permanente's Division of Research in Oakland, CA, presented data from a study evaluating the predictive performance of the BCI gene signatures (H/I and +MGI) among a large, independent population of 608 lymph node-negative breast cancer patients from a community hospital setting who either received tamoxifen or did not receive adjuvant therapy. Results suggest that, in this population of patients, the H/I and +MGI risk classifier is predictive of risk of breast cancer death. (Poster #4034)

Finally, on Friday, December 11, data were presented from a study in collaboration with Humphrey Gardner, MD of Novartis. These data demonstrate that the HOXB13 gene can predict response to neoadjuvant letrozole, an aromatase inhibitor, in patients with ER-positive breast cancer. Specifically, the data suggest that patients with low H/I have a three-fold greater response rate to letrozole as compared to patients with high H/I. This study reinforces the role of HOXB13 in the estrogen signaling pathway, and suggests that quantifying expression level of this gene could help physicians decide whether additional therapy is warranted in individual patients who have potentially low response rates to aromatase inhibitors. (Poster #2120)

"We are very excited about the outcome of these studies," said Richard Ding, chief executive officer of bioTheranostics. "Consistent with our previous work, this clinical evidence reinforces the clinical utility of the BCI assay. bioTheranostics is looking forw
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