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Data From LigoCyte's Clinical Studies of Norovirus VLP Vaccine Presented at 13th Annual Conference on Vaccine Research
Date:4/28/2010

ly brief. No vaccine-related serious adverse events occurred.  

"This is a unique example of a vaccine against an enteric virus that was well tolerated and highly immunogenic when given intranasally. The vaccine activated immune cells with the capacity to migrate to the gastrointestinal tract and produce antibodies that have the potential to prevent infection," said Marcela F. Pasetti, Ph.D., Associate Professor of Pediatrics at the University of Maryland School of Medicine, who presented the data at the Vaccine Research Conference. Dr. Pasetti also is chief of the Applied Immunology Section at the University of Maryland Center for Vaccine Development.

The investigational, nasally delivered, dry powder vaccine is currently being examined in a Phase I/II study designed to assess safety and immunogenicity plus potential protection against clinical symptoms of norovirus infection by including a live virus challenge of subjects that have received either the vaccine or placebo. The company expects to release interim results for this study next quarter. In addition, the company expects to begin a Phase I trial with an intramuscular version of norovirus VLP vaccine before the end of 2010.

About Norovirus Infection

Norovirus infection, well known as the "stomach flu," is the most common cause of acute gastroenteritis, afflicting nearly 23 million Americans annually. Norovirus infection is characterized by the acute onset of nausea, vomiting, abdominal cramps, diarrhea, and occasionally fever. Severe clinical outcomes are associated with at-risk populations, where complications caused by infection can disrupt primary treatment regimens and even lead to death. Noroviruses are highly infective and easily transmitted. Epidemic outbreaks occur in communit
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SOURCE LigoCyte Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
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