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Data From Clinical Study of bioTheranostics Molecular Diagnostic Test Presented at American Society of Clinical Oncology Annual Meeting
Date:6/1/2009

- THEROS CancerTYPE ID(R) predicts cancer origin with 75 percent accuracy in patients whose primary cancer was 'unknown' using traditional diagnostics -

SAN DIEGO, June 1 /PRNewswire/ -- bioTheranostics, a bioMerieux company that discovers, develops and commercializes new molecular diagnostic tests in oncology, announced that a recent study demonstrated the company's THEROS CancerTYPE ID(R) molecular diagnostic test predicted cancer origin with 75 percent accuracy in patients whose primary cancer was initially "unknown" using traditional diagnostics. Findings were presented today at the 2009 American Society of Clinical Oncology (ASCO) Annual Meeting in Orlando, Fl.

Three to five percent of all cancer patients(1) (the equivalent of 45,000-75,000 new patients each year in the United States alone) receive a diagnosis of cancer of unknown primary origin, or CUP, meaning their cancer has spread to multiple locations and the site where the cancer started can not be determined. Given that the origin of a cancer significantly impacts physicians' therapeutic decisions as well as patients' prognoses, the inability to diagnose patients' primary cancers makes it more difficult for physicians to determine optimal treatment plans. Molecular diagnostic tests such as the THEROS CancerTYPE ID have demonstrated the ability to predict the origin of tumors with a higher success rate than traditional diagnostic tests, thereby helping to reduce the number of cancers that remain "unknown".

The blinded study involved 28 patients who had an unknown primary cancer that was subsequently identified during their lives. Researchers assessed tissue from these patients' initial biopsies, determining that 20 of them were appropriate for testing with the THEROS CancerTYPE ID (eight were excluded given insufficient tumor tissue or poorly preserved RNA). Without accessing other clinical or pathological data for these patients, the team then co
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