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Data Demonstrating the Safety and Efficacy of Chimerix's Antiviral CMX001 Presented at BMT Tandem Meetings
Date:2/19/2013

KVN identified through biopsy or autopsy, and suggested that BKVN may be an under-recognized cause of renal dysfunction in HSCT recipients.  Through Chimerix's expanded access study of CMX001, a recipient of HSCT was treated for BKVN with CMX001 100 mg twice weekly for six months.  After 10 months of therapy, the patient has maintained stable renal function without requiring hemodialysis.  This case report suggests that BKVN may be underdiagnosed in HSCT recipients and should be considered in patients with declining renal function.  Furthermore, these data support the potential role of CMX001 for the treatment of BKV infection and BKVN.

About Chimerix and CMX001

Chimerix is committed to the discovery, development and commercialization of novel, oral antiviral therapeutics designed to transform patient care in areas of high unmet medical need.  The Company's proprietary lipid technology has given rise to two clinical-stage lipid acyclic nucleoside phosphonates, CMX001 and CMX157, which have demonstrated the potential for enhanced activity and safety in convenient, orally administered dosing regimens. 

Chimerix's lead product candidate, CMX001, is a broad spectrum, oral nucleotide analog lipid-conjugate that blocks replication of double-stranded DNA (dsDNA) viruses, including cytomegalovirus (CMV), adenovirus (AdV), BK virus and herpes simplex virus.  CMX001 has completed Phase 2 clinical development for the prevention of CMV in hematopoietic stem cell transplant (HSCT) recipients.  Chimerix is also conducting a Phase 2 study in HSCT recipients which is evaluating CMX001 as a preemptive therapy for AdV disease, an often-fatal infection which has no approved therapies.  Since 2009, Chimerix has made CMX001 available under expanded access regulations to over 80 transplant centers worldwide for the treatment of over 430 patients with life-threatening dsDNA viral infections.  Chimer
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SOURCE Chimerix, Inc.
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