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Data Demonstrating the Safety and Efficacy of Chimerix's Antiviral CMX001 Presented at BMT Tandem Meetings
Date:2/19/2013

RESEARCH TRIANGLE PARK, N.C., Feb. 19, 2013 /PRNewswire/ -- Chimerix, Inc., a biopharmaceutical company developing novel, oral antivirals in areas of high unmet medical need, today released data from presentations at the BMT Tandem Meetings supporting the broad spectrum antiviral activity and emerging safety profile of CMX001.  CMX001 is an oral nucleotide lipid-conjugate anticipated to start a Phase 3 study later this year.  

"These findings demonstrate CMX001's potential to be a safe and efficacious broad-spectrum antiviral for the treatment of double-stranded DNA viral infections," said M. Michelle Berrey , MD, MPH, Chief Medical Officer of Chimerix.  "As we progress CMX001 into a Phase 3 study for the prevention of cytomegalovirus infection in adults undergoing hematopoietic stem cell transplantation, these data support our desire to conduct additional clinical studies to evaluate the potential benefit of CMX001 against other double-stranded DNA viruses, including BK virus."

These data were presented during the Allogeneic Transplants Poster Session at the BMT Tandem Meetings in Salt Lake City on Saturday, February 16, 2013.

The three presentations included:

Renal Safety of the Broad-Spectrum Antiviral, CMX001, in the Prevention of Cytomegalovirus Infection Post-Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

Renal safety of CMX001 was assessed during Study 201, a Phase 2 study evaluating CMX001 for the prevention of CMV infection following allogeneic hematopoietic stem cell transplantation (HSCT).  A prospective analysis found that placebo recipients experienced a decline in renal function during the randomized treatment period, while there appeared to be a dose-related improvement in renal function for the CMX001-treated subjects.  The comparison between pooled placebo and the gro
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SOURCE Chimerix, Inc.
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