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Data Confirm Avastin(R) Helps Patients With Metastatic Colorectal Cancer Live Even Longer
Date:5/31/2008


BASEL, Switzerland, May 31 /PRNewswire/ --

- Thousands Of Patients Benefit Provided From Avastin-Based Therapy

A wealth of new Avastin (bevacizumab) data will be presented at the 44th annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago confirming that Avastin-based therapy is essential for patients with metastatic colorectal cancer (CRC). In total 15 separate data presentations will be made with highlights including:

1. Overall survival data confirmed in two large community-based studies,

including some 4,000 patients

2. First full data presentation of an Avastin and cetuximab combination

study

3. Impressive rates of curative surgery following treatment with Avastin

and chemotherapy

4. Survival benefits of Avastin confirmed with yet another chemotherapy

partner

1. Long-term overall survival reported by studies including almost 4,000 patients

The long-term benefits of Avastin use in combination with chemotherapy were confirmed by two large studies, which collectively included almost 4,000 patients with metastatic CRC. Key findings presented at ASCO from the First BEAT and BRiTE studies, which paired Avastin with chemotherapy of the investigator's choice, were:

- Avastin-based therapy provides a median overall survival benefit for patients of approximately two years (24.5 and 22.7 months from BRiTE and First BEAT respectively).

- Importantly, long-term Avastin exposure did not increase the risk of the patient suffering from Avastin-specific side effects. The incidence of Avastin-specific side effects were consistent with those reported in other scientific studies and were even less after one year of treatment.

2. Adding cetuximab to Avastin and chemotherapy decreases the time patients live without their disease getting worse

The first data presentation from the 755 patient CAIRO-2 study, which compared Avastin + chemo
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SOURCE Roche
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