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Data Analysis Reinforces the Safety Profile of Levemir(R)
Date:10/20/2009

PRINCETON, N.J., Oct. 20 /PRNewswire-FirstCall/ -- A meta-analysis of clinical data published today in Diabetologia, the medical journal for the European Association for the Study of Diabetes (EASD), demonstrated that the Novo Nordisk long-acting insulin Levemir® (insulin detemir [rDNA origin] injection) was not associated with any increase in the incidence of cancer when compared to human insulin(1,2).

The analysis conducted by Novo Nordisk assessed the relative risk of a cancer diagnosis during clinical treatment with Levemir®. It included approximately 9,000 patients (approximately 5,200 taking Levemir®) in 21 randomized controlled trials and compared the incidence of cancer in patients treated with Levemir® with that of patients treated with either human insulin (NPH insulin) or insulin glargine.

The data revealed that treatment with Levemir® was associated with a statistically significantly lower incidence of cancer than with NPH insulin treatment (0.36 events per 100 patient years in the Levemir® group vs. 0.92 events in the NPH insulin group; p<0.05).

The incidence of cancer during Levemir® treatment was also lower than that seen during treatment with insulin glargine, but this difference was not statistically significant (0.87 events per 100 patient years in the Levemir® group vs. 1.27 events in the insulin glargine group; p>0.05)(3).

"We have designed Levemir® with all aspects of safety for the patient in mind and these data are in line with what we would expect," said Dr. Alan Moses, Novo Nordisk Vice President and Chief Medical Officer. "Physicians, health care providers and patients can continue to feel confident in using Levemir® to effectively treat type 1 and type 2 diabetes."

The analysis was performed in response to the Diabetologia June publication of four registry studies(4). Those studies, while inconclusive due
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SOURCE Novo Nordisk
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