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Dainippon Sumitomo Pharma and Intercept Pharmaceuticals Announce Agreement to Develop and Commercialize Obeticholic Acid (INT-747) for Chronic Liver Disease
Date:3/30/2011

About Nonalcoholic Steatohepatitis (NASH)

NASH is a more serious form of nonalcoholic fatty liver disease (NAFLD) and occurs in patients who drink little or no alcohol. NASH occurs most commonly in obese and insulin resistant patients, but is also seen in lean individuals. In a report of a 5-10 year follow-up study, up to 25% of NASH patients progressed to cirrhosis of the liver.  The prevalence of NASH in Japan is estimated to be at least 1% of the adult population and pediatric disease is also becoming more common, while in the US it is estimated that 3-5% of the population has the disease in association with higher obesity rates. There is currently no approved treatment for NASH.

About Intercept Pharmaceuticals, Inc.

Intercept is a biotechnology company focused on discovering and developing small molecule drugs for the treatment of chronic liver and metabolic diseases.  The company's most advanced programs are focused on the development of modified bile acids that are selective for FXR, a nuclear receptor, and TGR5, a G protein-coupled receptor. Bile acid signaling through these receptors regulates key aspects of lipid, glucose and overall energy metabolism, while also serving to maintain the functional integrity of the liver, intestine and kidneys, organs that are exposed to bile acid flux. For more information about Intercept, please go to www.interceptpharma.com. CONTACT: Mark Pruzanski, M.D. or Barbara Duncan, both of Intercept, +1-646-747-1000. For information about Intercept's majority shareholder Genextra S.p.A., please go to www.genextra.it.

About Dainippon Sumitomo Pharma Co., Ltd. (DSP)

DSP is a multi-billion dollar, top-ten listed pharmaceutical company in Japan with a diverse portfolio of pharmaceutical products. DSP aims to produce innovative pharmaceutical products in the central nervous system (CNS
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SOURCE Intercept Pharmaceuticals, Inc.
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