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Daily 10 milligram dose of S-equol reduces menopausal symptoms effectively without impacting thyroid and sex hormones
Date:6/15/2013

Index (SMI), a rating scale for menopausal symptoms.   Women who had a greater than 50 percent response on the SMI scale while using a placebo during a four-week screening period prior to the treatment phase were excluded from the study.  The use of the 10 mg daily dose of S-equol was based on the data from the prior pilot dose-finding study, which determined that 10 mg of S-equol was the active dose needed to alleviate menopausal symptoms.

Some of the data presented at ENDO 2013 were previously published in The Journal of Women's Health, Online Ahead of Print: March 12, 2012 doi:10.1089 and The Journal of Nutrition July 2010 supplement doi:10.3945.   More information about the supplement containing S-equol, including results of other studies, is at http://www.naturalequol.com.

About Equol
S-Equol has the ability to bind to the same estrogen receptors as natural estrogen, with a stronger affinity to the estrogen receptor beta than the estrogen receptor alpha. On binding to these receptors, S-equol mimics some, but not all, activities of estrogen. Because of these actions at the receptor, it has been proposed that S-equol may alleviate some of the symptoms caused by diminished estrogen production during menopause.

The supplement is the product of fermentation of whole soy germ by lactic acid bacteria "Lactococcus 20-92" using a patented and proprietary process by the Otsuka Pharmaceutical Co., Ltd. The process results in the conversion of the daidzein to S-equol. The supplement containing S-equol is created under current Good Manufacturing Practices. Following fermentation, the bacteria undergo heat denaturation and are deactivated. The process is designed to produce an S-equol rich product, or nutraceutical ingredient. The ingredient has self-affirmed GRAS (Generally Recognized As Safe) sta
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