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Daily 10 milligram dose of S-equol reduces menopausal symptoms effectively without impacting thyroid and sex hormones
Date:6/15/2013

bacteria present in the large intestine and may be influenced by the amount of soy consumed. About 50 percent of Asians and 20 to 30 percent of North Americans and Europeans, who in general consume less soy than Asians, produce S-equol. Preliminary evidence from observational studies is emerging that suggests that women who are S-equol producers may experience fewer menopausal symptoms compared to non-producers.

Hormones Remain Steady, While Menopausal Symptoms Improve in Confirmation Study
Measurement of the sex hormones estradiol (estrogen), follicle stimulating hormone (FSH) and testosterone as well as of the thyroid hormones thyroid stimulating hormone (TSH), Free T4 (thyroxine) and Free T3 (triiodothyronine) documented no significant difference after 12 weeks of treatment in 77 women receiving 10 mg/daily of S-equol compared to 83 women receiving a placebo (p values ranged from 0.2092 to 0.3942).

Researchers assessed the effects of S-equol using the Climacteric Symptom Evaluation Form Checklist, which contains 22 menopausal symptoms. The women reported significant decreases in the severity of hot flashes as well as of muscle stiffness of the neck and shoulder after 12 weeks of treatment with S-equol compared to a placebo (p=0.015 for both).  Frequency of hot flash measures were also significantly reduced after 12 weeks of treatment, with hot flashes declining on average by 58.7 percent (-1.9 ± 1.8 episodes daily) with S-equol compared to 34.5 percent (-1.0 ± 2.0 episodes daily) with a placebo (p=0.009).

A separate measure using the Visual Analog Scale for menopausal symptoms documented a significant change in muscle stiffness of neck and shoulder after the 12-week treatment period for those receiving S-equol compared to a placebo (p=0.007).

The confirmation study evaluated 160 women aged 45 to 60 years, who had scored 25 or more on the Simplified Menopausal
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