Navigation Links
Daiichi Sankyo/Lilly Respond to ACCF/AHA Clinical Alert on Antiplatelet Therapy
Date:6/28/2010

nhibition of platelet aggregation.

The clopidogrel boxed warning states that patients considered "poor metabolizers" (those with two copies of the CYP2C19 variant) may have an increased risk of thrombotic cardiovascular (CV) events.  In addition, the label also notes that some patients with at least one reduced-function allele (copy) of CYP2C19 (also known as intermediate metabolizers) may also have a reduced response to clopidogrel.  The prevalence of poor metabolizers is estimated at 2 percent for Caucasians, 4 percent for Blacks, and 14 percent for Chinese. The prevalence of intermediate metabolizers is 28 percent for Caucasians, 33 percent for Blacks and 64 percent for Chinese.

In addition, the ACCF/AHA Clinical Alert suggests genetic variations in other genes, such as ABCB1, may also contribute to variability in response to clopidogrel.  A retrospective analysis of the TRITON-TIMI 38 trial suggested that patients treated with Effient with two variants in ABCB1 did not have an increased risk of thrombotic CV events when compared to patients treated with Effient without these variants.  

"The ability to convert Effient to its active metabolite is not known to be impacted by the key genetic variations discussed in the Clinical Alert," said Rogelio Braceras, MD, senior medical director, thrombosis at Daiichi Sankyo, Inc.  "In addition, other high-risk patient types mentioned in the Clinical Alert, such as those with diabetes or those who are more susceptible to recurrent events, such as STEMI patients, achieved reductions in the primary composite endpoint of CV death, nonfatal heart attack or nonfatal stroke in TRITON-TIMI 38 that were consistent with those observed in the UA/NSTEMI cohort and the overall all ACS population.  This benefit, however, should be weighed against the potential risk of clinically sign
'/>"/>

SOURCE Eli Lilly and Company
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Daiichi Sankyo Co, Ltd. Joins the National Cherry Blossom Festival in Washington D.C. as Centennial Celebration Committee Co-Chair
2. Daiichi Sankyo Initiates Largest Single, Double-Blind, Randomized, Phase III Trial for Treatment and Prevention of Recurrent Venous Thromboembolism
3. Daiichi Sankyo Initiates Phase III Trial of Its Investigational Factor Xa Inhibitor, DU-176b, in Patients With Atrial Fibrillation
4. Daiichi Sankyo and Lilly Respond to Speculation on Status of Prasugrel New Drug Application
5. Daiichi Sankyo Announces Clinical Study Data for Oral Factor Xa Inhibitor DU-176b
6. FDA Extends Review Period for Daiichi Sankyo, Lilly Investigative Antiplatelet Drug, Prasugrel
7. Daiichi Sankyo/Eli Lillys Effient and Astrazenecas Ticagrelor May Offer Advantages in the Treatment of Post-Myocardial Infarction
8. FDA Grants Priority Review for Daiichi Sankyo, Lilly Drug, prasugrel
9. Daiichi Sankyo and Forest Laboratories Finalize Contract for Co-Promotion of AZOR(TM)
10. Coalition for Pulmonary Fibrosis Responds to News of Further Review of Pirfenidone By FDA
11. New Science Education Program Responds to Presidents Call to Help Young People Excel in Science
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... , July 14, 2014 We are ... Center ("OACM") and the Ellicott City Ambulatory Surgery Center ... Ellicott City Maryland . ... Merritt Healthcare and 14 leading Orthopaedics, Sports Medicine, Hand, ... will also accommodate the specialties of general surgery and ...
(Date:7/14/2014)... de 2014 /PRNewswire-HISPANIC PR WIRE/ -- BioAdaptives, Inc. (OTCBB:BDPT) ... , presidente de la junta directiva, ha asumido las ... señor Epling es el dueño de Ferris Holding ... su formulación, sus propiedades intelectuales y otras tecnologías a ... "El señor Gerald Epling , que ha ...
(Date:7/14/2014)... July 14, 2014 Decision Resources Group ... positively influence perceptions of emerging drugs for both ... 100 oncologists (50 medical oncologists and 50 hematological ... of managed care organizations (MCOs), reveals that despite ... the majority of payers say this designation will ...
Breaking Medicine Technology:BioAdaptives se prepara para el próximo paso 2BioAdaptives se prepara para el próximo paso 3Breakthrough Therapy Designation is Likely to Sway Oncologists' Confidence in An Agent and Encourage Prescribing 2Breakthrough Therapy Designation is Likely to Sway Oncologists' Confidence in An Agent and Encourage Prescribing 3
... 2011  VIVUS, Inc. (NASDAQ: VVUS ) today ... in The American Journal of Clinical Nutrition, ... study evaluated the long-term efficacy and safety of Qnexa ... In addition to 10% sustained weight loss, the study ...
... Reportlinker.com announces that a new market research ... Global Coronary Stents Industry ... the worldwide markets for Coronary Stents in US$ ... Segments: Bare Metal Stents, and Drug Eluting Stents. ...
Cached Medicine Technology:SEQUEL Trial Results for Qnexa® Published in AJCN Show 10% Sustained Weight Loss Over 2 Years 2SEQUEL Trial Results for Qnexa® Published in AJCN Show 10% Sustained Weight Loss Over 2 Years 3SEQUEL Trial Results for Qnexa® Published in AJCN Show 10% Sustained Weight Loss Over 2 Years 4SEQUEL Trial Results for Qnexa® Published in AJCN Show 10% Sustained Weight Loss Over 2 Years 5SEQUEL Trial Results for Qnexa® Published in AJCN Show 10% Sustained Weight Loss Over 2 Years 6Global Coronary Stents Industry 2Global Coronary Stents Industry 3Global Coronary Stents Industry 4Global Coronary Stents Industry 5Global Coronary Stents Industry 6Global Coronary Stents Industry 7Global Coronary Stents Industry 8Global Coronary Stents Industry 9Global Coronary Stents Industry 10Global Coronary Stents Industry 11Global Coronary Stents Industry 12Global Coronary Stents Industry 13Global Coronary Stents Industry 14Global Coronary Stents Industry 15Global Coronary Stents Industry 16Global Coronary Stents Industry 17Global Coronary Stents Industry 18Global Coronary Stents Industry 19Global Coronary Stents Industry 20Global Coronary Stents Industry 21Global Coronary Stents Industry 22Global Coronary Stents Industry 23Global Coronary Stents Industry 24Global Coronary Stents Industry 25
(Date:7/14/2014)... According to a recent study ... a connection between women with high levels of a ... doctors have theorized about the role stress plays in ... provide scientific support. , “Stress, if very significant, can ... Barmat, an OB/GYN who specializes in reproductive endocrinology and ...
(Date:7/14/2014)... Last month Bromell Agency officially launched the new ... more detailed information on how clients can protect and ... boats in the state of Louisiana. , The agency ... website in order to better educate clients on the ... the website, which is to display comprehensive insurance information ...
(Date:7/14/2014)... 14, 2014 There’s an old adage that ... The Lash Palette say the products offered in their ... , “You can reserve The Lash Palette for $40,” said ... Store . , Paris explained that the first 1,000 have ... 21. , She went on to point out that her ...
(Date:7/14/2014)... 2014 Seven promising startup companies ... problems have been accepted into the University ... (DHA). , The awardees were selected from ... process. They include Biomeme, Fitly, Life Patch, Curbside ... France) and Pulse InfoFrame (from Canada) —both of ...
(Date:7/14/2014)... 2014 Jordan Valley Medical Center is ... comprehensive cancer center set to open by the fall ... only hospital west of I-15 in the Salt Lake ... Additionally, Jordan Valley Medical Center has partnered with Elekta, ... planning systems for radiation therapy, radiosurgery and brachytherapy, to ...
Breaking Medicine News(10 mins):Health News:Abington Health Physician Addresses Link Between Stress and Infertility 2Health News:Abington Health Physician Addresses Link Between Stress and Infertility 3Health News:The Lash Palette Preorder Event Has Officially Begun 2Health News:Seven Healthcare Startups Selected to Participate in University City Science Center’s First Digital Health Accelerator 2Health News:Seven Healthcare Startups Selected to Participate in University City Science Center’s First Digital Health Accelerator 3Health News:Seven Healthcare Startups Selected to Participate in University City Science Center’s First Digital Health Accelerator 4Health News:Jordan Valley Medical Center Set to Break Ground with New $10 Million Cancer Center 2
... day to day life. Keeping fit costs hardly anything if ... a gym or health club,// you'll be familiar with high ... These items typically cost thousands of dollars and might be ... But you can get the same results practically for free, ...
... lasers help remove lines and wrinkled from age and ... can take its toll in later years in terms ... But, says Dr Arielle Kauvar, a dermatologist at New ... smoother, firmer appearance. ,These lasers score over ...
... of botulinum toxin eases hand spasticity among stroke survivors. Spasticity ... and it causes much disability,// because it interferes with activities ... botulinum toxin - a substance that relieves muscle tightness - ... large trial of botulinum toxin (also known as botox) in ...
... may be combined with tumor growth in mice. At ... or similar pain medications will lead to increased cancer ... further studies for managing cancer pain. ,Researchers ... of morphine, similar to doses given to cancer patients ...
... potency can be influenced by various reasons. Many advertisments ... impotence to the attention of thousands of people.// Impotence ... men are taking help, particularly as large segments of ... range from 12 million to 30 million men in ...
... An acid found naturally in the body can block the ... There is no cure for Huntington's disease (HD), which is ... But researchers at the University of Texas may be one ... with HD. ,The mice were treated with a ...
Cached Medicine News:Health News:Many factors influence sexual potency 2
... and value!, Comfortable feel and ... contoured handle , Finer control while ... action , Completely autoclavable for easy ... for recalibration , Easy-to-read precision micrometer ...
... 3730 DNA Analyzer, upgradeable to 96 capillaries, ... analysis. , Higher optical sensitivity and ... data at a lower cost. , Multiple ... Optimized polymers increase your productivity without compromising ...
... this unique offer, you can ... application. Pipetman P2 and P10 ... reagents, and P100 is perfect ... Filter Tips, which are especially ...
... an immunochromatography based one step in ... determination of Methamphetamine in human urine ... ng/mL. This assay has not been ... and is for use by Healthcare ...
Medicine Products: