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DURECT Corporation Announces Third Quarter 2010 Financial Results
Date:11/3/2010

ECT a royalty on product sales.In the third quarter of 2010, we continued to enroll patients in our U.S. pivotal Phase III clinical study known as BESST (Bupivacaine Effectiveness and Safety in SABER Trial).  We expect to complete enrollment of BESST, comprising approximately 300 patients, in the first half of 2011.POSIDUR is our post-operative pain relief depot that utilizes our patented SABER technology to deliver bupivacaine to provide up to three days of pain relief after surgery. POSIDUR is licensed to Hospira for commercialization in the U.S. and Canada, and to Nycomed for commercialization in Europe and other defined countries. We have retained commercialization rights in Japan and all other countries not subject to the Nycomed and Hospira licenses.•

ELADUR (TRANSDUR™-Bupivacaine).  In October 2008, worldwide rights to this program were licensed to Alpharma, which was acquired by King Pharmaceuticals in December 2008.  In April 2010, King Pharmaceuticals initiated a Phase IIb trial evaluating the safety and efficacy of ELADUR in patients with chronic low back pain.  King expects to enroll approximately 260 patients in this study and we expect to receive top-line results from that study in the first half of 2011.  Assuming Pfizer completes its acquisition of King, Pfizer will assume the development and commercialization rights and obligations to ELADUR.ELADUR is our proprietary transdermal patch intended to deliver bupivacaine for a period of up to three days from each application.•

TRANSDUR-Sufentanil.  In February 2009, a successful end-of-Phase II meeting with the FDA was conducted for this program outlining a potential regulatory pathway for the Phase III program and NDA submission. During 2009, we transitioned the program back to our control.  We are in discussions with potential partners regarding licensing development and commercialization rights to this program to which we
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