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DSM Expands its Innovative Biomanufacturing Technology Portfolio With the Introduction of the New Kremer Method™

PARSIPPANY, N.J., June 28, 2011 /PRNewswire/ -- Royal DSM, the global Life Sciences and Materials Sciences company, today announced the introduction of the Kremer Method™, an innovative proprietary technology developed by DSM scientists which improves downstream processing of monoclonal antibodies (mAbs) for faster and more cost effective production of biopharmaceuticals.  The Kremer Method™ reduces processing and preparation times, labor and materials requirements and cost of goods for a more sustainable manufacturing platform.

DSM provides and develops technologies for optimizing mammalian cell culture processes. Examples are the proprietary XD® Technology for use with mammalian cell lines. The XD® process creates very high cell densities within the bioreactor, resulting in significant output enhancements of 5-15 fold using commercially available equipment.  In the downstream processing area, DSM's proprietary Rhobust® technology is the next generation in expanded bed chromatography (EBA), using cross linked agarose beads with Tungsten Carbide to increase the particle density. Rhobust® is applied as a direct capture and clarification step for mammalian and microbial harvest to increase yields, reduce the number of unit operations and reduce process cost.  The new Kremer Method™ further optimizes the downstream processing of proteins and monoclonal antibodies.

Karen King, President of DSM Biologics, a business unit of DSM Pharmaceutical Products, commented: "DSM is continually innovating to advance the world of biopharmaceutical manufacturing to the next level.  We are pleased to announce the introduction of the new DSP optimization technology, the Kremer Method™.  The combination of the Kremer Method™ with our other proprietary technologies significantly reduces the overall costs and processing times of biopharmaceuticals while maintaining high product quality."

Rolf Douwenga, Vice President of Global R&D for DSM Biologics explained: "The Kremer Method™ is a valuable addition to the platform of DSM's technologies addressing the full range of mammalian cell culture systems for protein and monoclonal antibody production. The method uses in-line dilution to streamline the purification and polishing of mAbs into one single continuous step in a flow-through mode. This eliminates the need for storage and reduces the amount of material usage such as buffers and resins. The Kremer Method™ reduces processing and preparation times, labor requirements and the cost of goods and presents an ideal solution to achieving cost effective processing."

After the capture step in conventional downstream processes, further purification and polishing of proteins are traditionally carried out as two separate batch unit operations. With the Kremer Method™ these steps are streamlined to work as one single unit operation.  Using this method; Host Cell Proteins (HCP's) were removed to a level below the limits of detection; complete aggregate removal was observed comparable to current state of the art processes; and recoveries of 90% were achieved. Several patent applications have already been filed.

XD® is a registered trademark of DSM

Rhobust® is a registered trademark of DSM

DSM – Bright Science. Brighter Living.™ DSM Pharmaceutical Products is a Business Group of Royal DSM N.V., a global science-based company active in health, nutrition and materials. By connecting its unique competences in Life Sciences and Materials Sciences DSM is driving economic prosperity, environmental progress and social advances to create sustainable value for all stakeholders. DSM delivers innovative solutions that nourish, protect and improve performance in global markets such as food and dietary supplements, personal care, feed, pharmaceuticals, medical devices, automotive, paints, electrical and electronics, life protection, alternative energy and bio-based materials. DSM's 22,000 employees deliver annual net sales of about euro 9 billion. The company is listed on NYSE Euronext. More information can be found at and more information:Karen King

Rolf DouwengaPresident, DSM Biologics

Vice President of Global R&D, DSM Biologics+1 973 257 8220

Tel: +1 973 257 Forward-looking statements

This press release may contain forward-looking statements with respect to DSM's future (financial) performance and position. Such statements are based on current expectations, estimates and projections of DSM and information currently available to the company. DSM cautions readers that such statements involve certain risks and uncertainties that are difficult to predict and therefore it should be understood that many factors can cause actual performance and position to differ materially from these statements. DSM has no obligation to update the statements contained in this press release, unless required by law. The English language version of the press release is leading.


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