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DSM Expands its Innovative Biomanufacturing Technology Portfolio With the Introduction of the New Kremer Method™
Date:6/27/2011

PARSIPPANY, N.J., June 28, 2011 /PRNewswire/ -- Royal DSM, the global Life Sciences and Materials Sciences company, today announced the introduction of the Kremer Method™, an innovative proprietary technology developed by DSM scientists which improves downstream processing of monoclonal antibodies (mAbs) for faster and more cost effective production of biopharmaceuticals.  The Kremer Method™ reduces processing and preparation times, labor and materials requirements and cost of goods for a more sustainable manufacturing platform.

DSM provides and develops technologies for optimizing mammalian cell culture processes. Examples are the proprietary XD® Technology for use with mammalian cell lines. The XD® process creates very high cell densities within the bioreactor, resulting in significant output enhancements of 5-15 fold using commercially available equipment.  In the downstream processing area, DSM's proprietary Rhobust® technology is the next generation in expanded bed chromatography (EBA), using cross linked agarose beads with Tungsten Carbide to increase the particle density. Rhobust® is applied as a direct capture and clarification step for mammalian and microbial harvest to increase yields, reduce the number of unit operations and reduce process cost.  The new Kremer Method™ further optimizes the downstream processing of proteins and monoclonal antibodies.

Karen King, President of DSM Biologics, a business unit of DSM Pharmaceutical Products, commented: "DSM is continually innovating to advance the world of biopharmaceutical manufacturing to the next level.  We are pleased to announce the introduction of the new DSP optimization technology, the Kremer Method™.  The combination of the Kremer Method™ with our other proprietary technologies significantly reduces the overall costs and processing times of biopharmaceuticals while maintaining high product qua
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