Navigation Links
DSM Announces Yield Boosts of 5-10 Fold With XD(R) Technology for Mammalian Manufacturing Platforms
Date:5/18/2009

PARSIPPANY, N.J., May 18 /PRNewswire/ -- DSM announced today that its proprietary XD(R) Technology boosts bioreactor productivity and titers of mammalian cell culture processes by 5-10 fold for the production of proteins and antibodies.

Recent studies completed at the R&D labs of DSM Biologics in Groningen, The Netherlands demonstrated that the yields from CHO-based cell cultures can be increased 5-10 fold over their previous fed-batch processes using only off the shelf, commercially available media. The XD(R) Technology has been tested for antibody and recombinant protein production across multiple cell lines, and the increase was realized in all cases.

By dramatically increasing the cell density of a culture, the XD(R) Technology offers the opportunity to substantially increase titers in a very short time without changing the cell line or process media. This can economically save a project already advanced in clinical development and prevent loss of time.

Jaap Schilder, Site Director Groningen, comments, "This opens the door to a completely novel way of supplying drug substance for clinical trials and for market needs. The XD(R) process increases the overall output of a facility dramatically and the process duration and handling is similar to any fed-batch process. Development spending, time to market and cost of goods will all be significantly reduced by applying this technology. Now, up to several kilograms of drug substance can be manufactured in a single batch from small disposable bioreactors."

Karen King, President at DSM Biologics, adds, "Our XD(R) Technology offers a substantial increase in titers and reactor output and has the potential to increase product quality as the producer cells are maintained at extremely high viability throughout the entire process. Clients can use the XD(R) Technology within their existing infrastructure or it can be the basis of an optimized new pla
'/>"/>

SOURCE DSM
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
3. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
4. ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer
5. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
6. Phosphagenics Announces Positive Phase 1b Transdermal Insulin Clinical Trial Results
7. Xenomics Announces Implementation of its First Diagnostic Test for Acute Myeloid Leukemia Into Clinical Practice
8. Emisphere Technologies, Inc. Announces 2007 Second Quarter Financial Results
9. Amicus Therapeutics Announces Second Quarter 2007 Financial Results
10. Genta Incorporated Announces Second Quarter 2007 Financial Results and Corporate Highlights
11. MicroDose Announces Positive Results From the QDose Inhaled Insulin Glucose Clamp Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... , Jan. 23, 2015  MedScope ( www.medscope.org ), the ... for a 2015 Connected World magazine Connected ... System (mPERS), that can be used anywhere, anytime. The ... In nominating MedScope, Landon Garner ...
(Date:1/23/2015)... Rose, baseball,s all-time hits leader, is the new spokesperson for ... Pharma has announced. "Pete,s a Hall of Famer ... on board with Myoflex," said Ducere Pharma Chief Executive Officer ... is known across all generations. The passion and intensity that ...
(Date:1/23/2015)... , Jan. 23, 2015  Lixte Biotechnology Holdings, Inc. (OTCQB: LIXT), ... I trial of Lixte,s lead compound, LB‑100, is being conducted, ... John S. Kovach , M.D., the founder and President ... be completed at a single site. Accrual of patients, however, ...
Breaking Medicine Technology:MedScope Nominated by RacoWireless for Prestigious 2015 Connected World Magazine Connected World Award 2Pete Rose bets on Myoflex to relieve aches and pains 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 3
... Denali Concrete Management Inc. (OTCBB: DCMG) announced today ... acquisition of Denali by Can-Fite BioPharma Ltd. (TASE: CFBI) ... outstanding shares of EyeFite Ltd., a private company incorporated ... exclusive license over CF101 for ophthalmic indications. Concurrently, Denali ...
... 22, 2011 Par Pharmaceutical Companies, Inc. (NYSE: ... approved the promotions of Thomas J. Haughey to the role ... Chief Operating Officer of the Company and its subsidiaries, effective ... LePore who will retain his title of Chairman of the ...
Cached Medicine Technology:Denali Concrete Management Inc. Announces its Acquisition of CF101 for Ophthalmic Indications and the Completion of Above $6 Million Private Placement at $1.144 Per Share 2Denali Concrete Management Inc. Announces its Acquisition of CF101 for Ophthalmic Indications and the Completion of Above $6 Million Private Placement at $1.144 Per Share 3Par Pharmaceutical Companies Promotes Thomas J. Haughey to President and Paul V. Campanelli to Chief Operating Officer 2
(Date:1/22/2015)... Blue Cross and Blue Shield of Minnesota (Blue Cross) ... to “Live Fearless.” , The “Faces of Fearless” ... about how they or someone they know has faced a ... the moment. By telling these types of stories through livefearlessmn.com, ...
(Date:1/22/2015)... A new white paper by The Beryl ... the long-term care environment as well as provides recommendations ... paper, “The Power of Person-Centeredness in Long-Term Care: A ... the patient, resident and family experience in long-term care ...
(Date:1/22/2015)... 2015 Carinsurancesavings.biz has released a new blog ... dismemberment insurance . , Purchasing an accidental death and ... advantageous. This type of rider provides benefits if the insured ... considered a lesser form of life insurance. , AD&D ...
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne wedding ... annual revenues in the past three years. Today, the business ... , According to the sales manager of the company, this ... in 2015. This point can be reflected on the discounted ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 EBSCO Information ... (AMA) are expanding their relationship in an effort to further ... the world. While EBSCO has long made AMA journals available ... sales agent for The JAMA Network. , Long ...
Breaking Medicine News(10 mins):Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4
... , , , OAKLAND, Calif., ... host a Breema Intensive on February 6-14, 2010. The Intensive program ... to help advanced students deepen their practice of Breema and its ... Oakland, California. Participants can choose from a 2-day, 3-day or 6-day ...
... ... the more than 200 available models can be a daunting task. To ease the ... a series of eBooks on electric mobility scooters. Don’t get stuck in the mud ... ...
... ... rehab based in Texas, announced today that it has expanded its’ continuum of care with ... ... Origins Recovery, LLC announced today that it has expanded its’ continuum of care to include ...
... 28 The Providence Service Corporation (Nasdaq: PRSC ) ... last week by the United States Senate. The Senate ... Bill and therefore could still undergo substantial changes, has a ... many of the types of home and community based social ...
... have created what appears to be a schizophrenic mouse ... complex reasoning and decisions about appropriate social behavior. ... 28 in PNAS, elucidate the critical balance between excitation ... awry in schizophrenia. They also provide the first animal ...
... , NEW YORK, Dec. 28 The Michael J. ... $2 million to five research teams carrying out clinical studies ... in Parkinson,s disease, and help speed the development of urgently ... lead gift from The Edmond J. Safra Foundation, a steadfast ...
Cached Medicine News:Health News:The Breema Center Announces Its Winter Intensive 2Health News:The Breema Center Announces Its Winter Intensive 3Health News:Will Your Purchase of an Electric Mobility Scooter Lead to a Comedy of Errors? 2Health News:Will Your Purchase of an Electric Mobility Scooter Lead to a Comedy of Errors? 3Health News:Will Your Purchase of an Electric Mobility Scooter Lead to a Comedy of Errors? 4Health News:Origins Recovery Centers Announces an Expansion of its Continuum of Care 2Health News:Origins Recovery Centers Announces an Expansion of its Continuum of Care 3Health News:Providence Service Corporation Comments on Senate Health Care Reform 2Health News:Providence Service Corporation Comments on Senate Health Care Reform 3Health News:Schizophrenia mouse model should improve understanding and treatment of the disorder 2Health News:Michael J. Fox Foundation Awards $2 Million for Clinical Research on Postural Instability and Gait Disturbances in Parkinson's Disease 2Health News:Michael J. Fox Foundation Awards $2 Million for Clinical Research on Postural Instability and Gait Disturbances in Parkinson's Disease 3
Used for dilation of a tract to the kidney for removal of stones. Supplied sterile in peel-open packages. Intended for one-time use....
... supplied on Smart Cards. Insert the card and ... and turns itself off after the programmed time. ... duration of treatments. Simply provide your patient with ... their progress on the next visit.,The initial set ...
... painfree therapy stimulates the spincter and ... contractions and relaxation. By use of ... surgical operations (bladder liftings) may be ... can improve unsatisfying results. DETRUSAM intravesical ...
... ELPHA 4 Conti is a battery operated ... treatment of conditions described below. ELPHA 4 Conti ... In STRESS- and faecal incontinence ELPHA 4 Conti ... that the user can feel which muscles need ...
Medicine Products: