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DNA Test Predicts Harmful Effects of Cancer Drug
Date:8/28/2007

ic test available for a medicine is valuable, but so is knowing when to use that test, said Dr. Richard Goldberg, a co-author of the study and physician in chief of the Carolina Cancer Hospital.

"There are so many treatment options for cancer patients that the more information we have about matching the right therapy to the patient, the better off we all are," Goldberg said. "Studies like this one give oncologists the tools needed to take better care of patients while avoiding unnecessary tests and expenses."

The authors recommended that the FDA amend the product information for irinotecan to describe the association between irinotecan dose and risk of hematologic toxicity among patients with two UGT1A1*28 genes.

About the authors: McLeod is the Fred Eshelman Distinguished Professor at the UNC School of Pharmacy. Goldberg is the associate director of UNC's Lineberger Comprehensive Cancer Center and chief of the UNC Division of Hematology/Oncology. Hoskins is of the UNC School of Pharmacy. Qu and Ibrahim are of the UNC School of Public Health.

For more information about this study, please contact Professor Howard McLeod, Director, UNC Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill by phone at 919-966-0512 or 314-420-8182, or by email at hmcleod@unc.edu.


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SOURCE University of North Carolina at Chapel Hill
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