Navigation Links
DG041 Blocks Platelet Aggregation Through a Novel Mechanism and does not Increase Bleeding Time When Given Alone or with Plavix(TM) or Aspirin
Date:6/30/2008

n genetics work in peripheral artery disease, stroke and heart attack, DG041 has been shown to offer a novel approach to inhibiting platelet aggregation where it is needed -- at the site of lesions in the vasculature. One of the most compelling results coming out of this study is that DG041 was shown to substantially inhibit EP3 mediated platelet activation that is not being addressed by current therapy. This suggests that DG041 may have a favourable profile not only as a first-line therapy, but also as a combination therapy with existing standard of care. We are encouraged by these results and look forward to advancing DG041 into later stage trials with a strategic partner," said Kari Stefansson, CEO of deCODE.

About DG041

deCODE's medicinal chemistry group discovered DG041 as a means to prevent arterial thrombosis by inhibiting the activity of EP3. In Phase I and Phase IIa clinical trials and follow-on clinical pharmacology studies, DG041 has been shown to dramatically inhibit platelet aggregation as well as platelet activation mediated specifically through vasodilator-stimulated phosphoprotein (VASP), a biomarker useful for measuring platelet activity. Following deCODE's gene discovery work linking this pathway with arterial disease, work by leading international scientists demonstrated in mice that PGE2 is produced in atherosclerotic plaques, promoting the formation of clots immediately at the sites of plaque but not over normal blood vessels. The formation of these thrombi is dependent on signaling through EP3. This pathway is left largely unaffected by existing anti-platelet drugs such as aspirin and Plavix(TM). deCODE is actively pursuing partnership opportunities for the latter phases of the clinical development of DG041.

About deCODE

deCODE is a biopharmaceutical company applying its discoveries in human genetics to the development of diagnostics and drugs for common diseases. deCODE is a global leader in gene discovery - our pop
'/>"/>

SOURCE deCODE genetics
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Cleveland Clinic Researchers Identify Mechanism Behind Platelet Function and Potentially Fatal Blood Clot Formation
2. Addition of INTEGRILIN(R) (Eptifibatide) to Bivalirudin Plus Standard of Care Inhibits Platelet Aggregation in Patients Undergoing Elective Coronary Stenting
3. SCH 530348 (TRA), a Novel Investigational Antiplatelet Agent, Shown to Inhibit Platelet Aggregation in PCI Patients
4. Cogentus to Launch Phase III Program of Novel Combination Product Designed to Reduce Bleeding Side Effect of Antiplatelet Therapy
5. Cogentus Pharmaceuticals Begins Clinical Study to Confirm the Full Antiplatelet Benefit of New Combination Medicine CGT-2168
6. New Data Show High Frequency of Medical Claims for Gastrointestinal Events by Patients on Antiplatelet Therapy
7. FDA Extends Review Period for Daiichi Sankyo, Lilly Investigative Antiplatelet Drug, Prasugrel
8. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
9. Novel Technology Breaks Through Cancer Pain
10. WallSt.net (www.wallst.net) Updates the Investment Community Through an All-New Interview With RegeneRx Biopharmaceuticals CEO
11. Trana Discovery and Southern Research Institute Announce the First RNA-RNA High Throughput Drug Screening Assay Platform for HIV Antivirals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)...  Unilife Corporation ("Unilife" or "Company") (NASDAQ: ... of injectable drug delivery systems, today announced an ... facilities in response to increasing demand from pharmaceutical ... During the fourth quarter of fiscal year 2014, ... expenditures and R&D above normal quarterly investments. ...
(Date:7/30/2014)... N.Y. , July 30, 2014 /PRNewswire-iReach/ -- ... -based medical device company, has announced today ... the velox CD™ Vascular Closure Device. Velox CD™ ... immediate hemostasis following percutaneous femoral procedures. The single ... broadly ranging in size from 5F to 8F.  ...
(Date:7/30/2014)... -- InnoPharma, Inc. today announced the first generic launch of ... injection), in Canada.  Olanzapine is indicated for the rapid ... schizophrenia or bipolar I mania. As the ... into an agreement with Sandoz Canada Inc., pursuant to ... market and distribute Olanzapine Injection in Canada ...
Breaking Medicine Technology:Unilife Accelerates Investment to Meet Increasing Demand from New and Existing Customers 2Unilife Accelerates Investment to Meet Increasing Demand from New and Existing Customers 3Unilife Accelerates Investment to Meet Increasing Demand from New and Existing Customers 4Unilife Accelerates Investment to Meet Increasing Demand from New and Existing Customers 5Transluminal Technologies receives CE Mark approval for velox CD(TM) vascular closure device 2InnoPharma Announces Launch of Olanzapine for Injection, 10mg/vial in Canada 2
... Ill., Dec. 21, 2010 The American Veterinary Medical Association ... new federal guidelines on a useful and effective induction agent, ... making propofol a Schedule IV drug.  In a letter to ... the DEA keep this effective drug, which typically causes few ...
... Dec. 21, 2010 Based on its recent ... & Sullivan recognizes Cambridge, Mass.-based Semprus BioSciences with ... Award for Surface Functionalization Technologies . The company,s ... designed to reduce the complications associated with implanted ...
Cached Medicine Technology:AVMA Offers Important Guidance to DEA on New Controls for Induction Agent—Propofol 2Frost & Sullivan Presents the 2010 North American Enabling Technology of the Year Award for Surface Functionalization Technologies to Semprus BioSciences 2Frost & Sullivan Presents the 2010 North American Enabling Technology of the Year Award for Surface Functionalization Technologies to Semprus BioSciences 3
(Date:7/30/2014)... Nationally recognized leader in nursing education, ... September 2013 has served as president of the ... of the College of Nursing at University of Alabama-Huntsville ... of the NLN, as the nation's premier voice for ... and research institutions in the country. , "The ...
(Date:7/30/2014)... Ticket Down is a reputable source for ... friendly exhibition match at the Red Bull Arena in ... that was left standing as the best team in the ... largest football competition and even embarrassed the host nation Brazilian ... Germany was led by seven players that called Bayern Munich ...
(Date:7/30/2014)... July 30, 2014 Ticket Down is ... Tickets in Ann Arbor, MI on Saturday, August 2nd. ... international football will be competing on American soil on Aug. 2 ... in Ann Arbor, Mich. The home of the University of Michigan ... the most prestigious in all of American sports and has also ...
(Date:7/30/2014)... 2014 (HealthDay News) -- It can happen in an instant: ... or computer monitor and gets critically injured when the furniture ... child should look around their homes and imagine what could ... it is better than it becoming a reality," Dr. Alex ... in a college news release. Between 2009 and 2011, ...
(Date:7/30/2014)... Lexington, MA (PRWEB) July 30, 2014 ... provider of authentication, access management and secure communications ... Imprivata OneSign ® is the most widely ... using McKesson Paragon or Horizon electronic medical records ... (an increase of about 11 percent in the ...
Breaking Medicine News(10 mins):Health News:National League for Nursing Congratulates League President Marsha Adams on Appointment as Dean of College of Nursing at University of Alabama-Huntsville 2Health News:National League for Nursing Congratulates League President Marsha Adams on Appointment as Dean of College of Nursing at University of Alabama-Huntsville 3Health News:Bayern Munich vs. Chivas Guadalajara Tickets Red Bull Arena: Ticket Down Slashes Ticket Prices for Chivas Guadalajara vs. Bayern Munich in Harrison, NJ 2Health News:Bayern Munich vs. Chivas Guadalajara Tickets Red Bull Arena: Ticket Down Slashes Ticket Prices for Chivas Guadalajara vs. Bayern Munich in Harrison, NJ 3Health News:Manchester United vs. Real Madrid Tickets Ann Arbor: Ticket Down Slashes Ticket Prices for Real Madrid vs. ManU Guinness International Champions Cup Match 2Health News:Manchester United vs. Real Madrid Tickets Ann Arbor: Ticket Down Slashes Ticket Prices for Real Madrid vs. ManU Guinness International Champions Cup Match 3Health News:Manchester United vs. Real Madrid Tickets Ann Arbor: Ticket Down Slashes Ticket Prices for Real Madrid vs. ManU Guinness International Champions Cup Match 4Health News:Tip-Over Furniture Can Kill Kids 2Health News:Imprivata Achieves 51 Percent Single Sign-on Market Share Amongst U.S. Hospitals Using McKesson Paragon or Horizon EMR Systems, According to HIMSS Analytics 2
... Health Minister Anbumani Ramadoss, has called a meeting of ... measures to be taken to control the mosquito-borne disease, ... Pradesh, Tamil Nadu, Kerala, Karnataka, Puducherry, Gujarat, Maharashtra, Goa ... ministry official said. ,The Ministers would also ...
... up a holistic tourism centre that will promote medical ... Kodiyeri Balakrishnan said here Wednesday . ... ayurveda, farm tourism and medical tourism," Balakrishnan told the ... Indian Industry (CII) was currently preparing a report for ...
... in normal peoples sleep. Some are light sleepers, whereas ... others take their time . ,Such ... differences in circumstances, habits, and other non-biological factors. But ... research professor and assistant director of the Sleep and ...
... procedures among most notable increases. Approximately 225,800 hair ... 34 percent from 2004, according to statistics ... by the International Society of Hair Restoration Surgery ... hair loss and hair restoration. ,This large ...
... at the Washington University School of Medicine in St. ... the butt by revealing that smoking interferes with ... a mouse model and found that cigarette smoking impairs ... delays healing following ligament repair surgery. ...
... Scientists at University of Alabama at Birmingham (UAB) have ... bacteria RNA and that in human RNA , a ... less antibiotic resistance. ,The new findings have ... Dmitry Vassylyev, Professor of Biochemistry and Molecular Genetics. ...
Cached Medicine News:Health News:Kerala to Set Up Holistic Tourism Centre to Promote Medical Tourism 2Health News:Individual Differences in Sleep Structure are Biologically Determined 2Health News:Hair Restoration Procedures Performed Worldwide Increased 34 Percent in 2006 2Health News:Hair Restoration Procedures Performed Worldwide Increased 34 Percent in 2006 3Health News:Smoking Hampers Healing of the Ligament 2Health News:Scientists Trace New Pathway That may Stem Antibiotic Resistance 2
Coolpix 4500 microscope package includes Coolpix 4500 digital camera, MDC-A relay lens and EH52 AC adapter....
... Fully automatic clinical chemistry & immunoturbidimetry ... fixed time and immunoturbidimetric methods. EOS ... batch analyzer designed to perform tests ... It can work in end point ...
... Stains for Geometric Data Hemastainer. ... Stains are quality control tested ... ensure proper staining and absence ... applications for a minimum of ...
Wright Stain Solutions...
Medicine Products: