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DFH Pharma Obtains Exclusive Rights to Second-Generation HIV Maturation Inhibitor Program
Date:11/1/2011

ere are 32 approved antiretroviral drugs and combination products there are only five validated targets in the viral lifecycle. Research has shown that multiple drugs acting against the same viral target can result in resistance development, the main cause of HIV treatment failure. Additionally, cross-resistance to drugs within the same class is an increasingly important consideration in the long-term treatment of HIV infection. Because maturation inhibitors represent a new class of antiretroviral agents, they are expected to retain activity against drug-resistant virus, and their successful development would offer additional treatment options to patients no longer responding to the currently available therapies. "I believe that maturation inhibitor drugs for the treatment of HIV infection can and should be developed", said Dr. Mark Wainberg, Professor at McGill University, Director of the McGill AIDS Centre and a leader in the field of HIV drug resistance, "Second generation maturation inhibitors that overcome the resistance related problems of the first generation candidates could provide the basis for the further clinical development of this novel class of HIV drugs".

About Maturation Inhibitors

Maturation inhibitors are a novel class of antiretroviral drug candidates that inhibit HIV-1 replication by interfering with the maturation of the HIV-1 virus. Specifically, drugs in this class interfere with the last step in the processing of the HIV-1 Gag protein. This interference leads to the formation of noninfectious, immature virus particles, thus preventing subsequent rounds of HIV infection. As expected for a novel mechanism of action, these drugs retain inhibitory activity against HIV-1 isolates resistant to all classes of currently approved drugs commonly used by HIV infected patients. DFH plans to develop maturation inhibitors for application in both first-line and salvage therapy.

About DFH Pharma, Inc.

DFH founders
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SOURCE DFH Pharma, Inc.
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