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DEFLUX(R) Significantly Reduces Urinary Tract Infections in Children With Vesicoureteral Reflux
Date:8/19/2007

h postoperative VCUG. All patients were kept on prophylactic antibiotics for three months after DEFLUX injection.

After treatment with DEFLUX, 13 percent of patients (n=13) had recurrent UTIs compared to 75 percent (n=75) before DEFLUX treatment, with a five-fold reduction in the incidence of UTIs per year (0.12 +/- 0.04 (p=0.001) post- treatment versus 0.68 +/- 0.09 pre-treatment). DEFLUX also eliminated the need for prophylactic antibiotics in 87 percent of patients. Of the 13 patients with recurrent UTIs after DEFLUX treatment, eight experienced them when they were no longer taking antibiotics. The overall success rate by ureter of DEFLUX treatment in resolving VUR was 77.4 percent after the first injection and 83.9 percent after a second injection. There were no major intraoperative or postoperative complications.

Additional Study Supports Data

A long-term observational study of 179 children with VUR, published in the November 2006 issue of the Journal of Pediatric Urology, showed that in children successfully treated with DEFLUX 74.9 percent of patients experienced no UTIs in the seven-to-12-year follow-up period after DEFLUX treatment (all experienced at least one UTI before treatment). Additionally, 96.6 percent experienced no febrile UTIs (UTIs accompanied by fever) in the follow-period. Most of the post-treatment UTIs reported occurred more than one year after treatment (82.2 percent). Study participants, treated with DEFLUX between 1993 and 1998, were asked to complete a 21-item questionnaire, with parental assistance if required.

DEFLUX, injected endoscopically where the ureter joins the bladder, is typically administered under general anesthesia as an outpatient procedure. The procedure is quick to perform (approximately 15 minutes) and no incision is required. The majority of VUR patients in the U.S. are managed with either antibiotics or an invasive surgical procedure that, while highly effective, requires hospitalization and ca
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SOURCE Q-Med

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