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DEFLUX(R) Significantly Reduces Urinary Tract Infections in Children With Vesicoureteral Reflux
Date:8/19/2007

- Need for Antibiotics Eliminated in 87 Percent of Patients, New Study

Finds -

PRINCETON, N.J., Aug. 7 /PRNewswire/ -- DEFLUX(R) (non-animal stabilized hyaluronic acid/dextranomer gel), for the treatment of vesicoureteral reflux (VUR) in children, reduced the incidence of recurrent urinary tract infections (UTIs) in children with VUR by 62 percent, according to a study published in the July issue of the Journal of Laparoendoscopic & Advanced Surgical Techniques. DEFLUX also eliminated the need for prophylactic antibiotics in 87 percent of patients. VUR, a malformation of the ureter that causes a backflow of urine from the bladder toward the kidneys, is the most common abnormality of the urinary tract in children. UTIs are the primary indicator of pediatric VUR and if left untreated, may lead to kidney damage.

"The primary goal of VUR treatment in children is to reduce the incidence of UTIs, which over time can lead to long-term health consequences including renal scarring and hypertension," said Kevin P. Moriarty, MD, FACS, FAAP Clinical Associate Professor of Surgery, Tufts University School of Medicine. "In this study we see that DEFLUX is not only effective in resolving VUR, but also in reducing the incidence of UTIs and use of antibiotics, which require long-term compliance and can increase the potential of resistance. These data add to the growing body of evidence supporting DEFLUX as first-line treatment for VUR."

In this prospectively designed study, the charts of 100 children aged one to 17 years with VUR from Baystate Children's Hospital, Tufts University School of Medicine, Springfield, Massachusetts were reviewed. Inclusion criteria included Grades II-IV VUR determined by voiding cystourethrogram (VCUG) with breakthrough UTIs despite prophylactic antibiotics. The frequency of UTIs was recorded before and after treatment with DEFLUX. Success was defined as the resolution of reflux on a three-mont
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SOURCE Q-Med

Copyright©2007 PR Newswire.

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