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Cytokine Announces Oral Efficacy of Anti-Cytokine Semapimod
Date:10/29/2007

arco Bruno (AMC, Amsterdam, The Netherlands) tested semapimod IV for prevention of ERCP-induced pancreatitis. He stated: "The trial showed a clear trend toward efficacy when semapimod was used prophylactically. The reductions in the pancreatitis rate and amylase levels were impressive when one considers that this was a single dose treatment where we did not know the optimal dose. Larger scale studies are clearly warranted."

The ability to dose orally is viewed as a considerable advance in the development of semapimod. Dr. Thais Sielecki, Director of Research at CPSI, commented: "As a synthetic small-molecule, semapimod holds the promise of a more cost-effective alternative to expensive and difficult-to-manufacture biologics. Oral dosing would also make treatment much easier than the IV and subcutaneous routes, which are currently the only options for many patients."

The new salts have demonstrated their ability to reduce cytokine levels when given orally in a preclinical sepsis model. CPSI has recently obtained a patent on these new salts (US 7,244,765), giving considerable patent life for the reformulated product.

The company is ready to move these new salts into clinical trials and is seeking a partner to assist with their development plan.

About Cytokine PharmaSciences, Inc.

Cytokine PharmaSciences is a biopharmaceutical company located in King of Prussia (near Philadelphia), Pennsylvania. The company licenses technologies from academia and other sources, develops products from those technologies and outlicenses the products to third parties for marketing. For more information, visit to http://www.cytokinepharmasciences.com.


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SOURCE Cytokine PharmaSciences, Inc.
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