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Cymbalta(R) Significantly Reduced Osteoarthritis Knee Pain in New Study
Date:1/30/2009

INDIANAPOLIS, Jan. 30 /PRNewswire-FirstCall/ -- In a new study, Cymbalta (duloxetine HCl) 60-120 mg, taken once daily, reduced pain severity significantly, compared with placebo, in patients with osteoarthritis pain of the knee. Data from the 13-week randomized, double-blind, placebo-controlled clinical trial(1) were presented at the annual meeting of the American Academy of Pain Medicine (AAPM) in Honolulu, Hawaii.

Duloxetine-treated patients showed greater reductions from baseline on the primary endpoint, the 24-hour average pain score on the Brief Pain Inventory (BPI), compared with placebo-treated patients. In the study, 65 percent of duloxetine-treated patients experienced a clinically significant (at least 30 percent) improvement in pain, compared with 44 percent of placebo-treated patients.

The duloxetine-treated patients also showed improved physical function, compared with placebo-treated patients, as measured by the Western Ontario and McMaster Osteoarthritis Index (WOMAC). In this study, patients on duloxetine did not show statistically significant improvements on the WOMAC pain and stiffness subscales compared with placebo.

"The disabling nature of osteoarthritis pain can greatly impact a person's life," said Vladimir Skljarevski, M.D., a study author and medical fellow at Eli Lilly and Company. "As our population ages, osteoarthritis of the knee is likely to become an increasing problem."

The most common adverse events in the study (occurred at a rate of greater than or equal to 5 percent and at least twice the rate of placebo) included nausea, constipation and excessive sweating (hyperhidrosis). Adverse events were similar to those seen in previous duloxetine studies.

Additional Study Highlights

-- Compared with patients receiving placebo, patients receiving duloxetine experienced additional improvements associated with osteoarthritis
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SOURCE Eli Lilly and Company
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