Navigation Links
Cylene Selected to Present CK2 Inhibitor Multiple Myeloma Data at American Society of Hematology Meeting
Date:12/6/2010

4;BSignaling and Induces Apoptosis in Multiple Myeloma Cells

Session: Myeloma – Pathophysiology and Preclinical Studies, excluding Therapy: Multiple Myeloma – Molecular Target-Based Therapy

Location: Orange County Convention Center, 314

About CK2 and CX-4945

Protein kinase CK2 has emerged as a validated drug target for cancer therapy due to its dysregulation andoverexpression in tumors and its regulatory roles in cell cycle control, DNA damage repair, and in the PI3K/Akt, JAK/STAT, IL-6 and NF-κB signaling cascades.  These pathways have specific relevance in multiple myeloma progression and high levels of CK2 overexpression characterize the disease.  CX-4945 is a potent and highly selective, small molecule inhibitor of CK2 and is currently under evaluation as an orally administered single agent in a Phase I clinical trial in patients with solid tumors (including breast, prostate, pancreatic cancers and inflammatory breast cancer) and a separate Phase I trial in patients with multiple myeloma has recently been initiated.  During the solid tumor trial, CX-4945 has established favorable pharmacokinetic, pharmacodynamic and safety profiles.  Measurement of mechanism and tumor-related biomarkers in patients reveal that CX-4945 hits the CK2 target and down-modulates the PI3K/Akt pathway.  The pharmacokinetic and biomarker data demonstrate that CX-4945 is achieving pharmacologically active levels in plasma and in tumor cells and elicits a clear pharmacodynamic response in humans.  Together, the findings establish CX-4945 as a promising therapeutic agent for targeting multiple cancers.

About Cylene Pharmaceuticals

Cylene Pharmaceuticals, Inc. is a San Diego-based, private biotechnology company, discovering and developing targeted small molecule drugs to treat life-threatening cancers.  Cylene's drug discovery platform, STAND (Selective
'/>"/>

SOURCE Cylene Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Cylene to Present Advances with Industrys Only Clinical CK2 Inhibitor, CX-4945, at EORTC-NCI-AACR
2. Cylene to Present Advances in its Oral Inhibitor of CK2 at AACR Annual Meeting
3. Cylene Pharmaceuticals Initiates Phase I Trial With CX-4945 -Breakthrough First-in Class Inhibitor of CK2
4. GENFIT Selected by Windhover for the 2011 Top Biopharma Projects To Watch
5. PolyOne GLS Selected as Healthcare Industry Marketing Specialist for Santoprene™ TPV Medical Grades
6. Sinovac Selected by Beijing CDC to Supply Seasonal Flu Vaccine Anflu(R) to Beijing Citizens
7. CSA Medical Selected to Present at AdvaMed 2010: The MedTech Conference
8. The Colorado Institute for Drug, Device and Diagnostic Development Announces Companies Selected From Its First Solicitation: Sophono, Inc., Receiving $600K; and PeptiVir, Inc., $300K
9. Neuronetics Selected by World Economic Forum as 2011 Technology Pioneer
10. Greenway Selected by Health Information Exchanges and Regional Physician Groups
11. Award-Winning Thermal Angel Selected as Winner for Outstanding Military Product of the Year
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2015)... NEW YORK , Sept. 2, 2015 ... pharmaceutical and medical device company focused on oncology with ... liver cancers, announces that Company management will participate in ... Conference being held from September 8-10, 2015 at the ... Simpson , PhD, MSN, CRNP, Delcath,s President and Chief ...
(Date:9/2/2015)... CytoSorbents Corporation (NASDAQ: CTSO ), a ... blood purification technology to reduce deadly uncontrolled inflammation in ... Phillip Chan , MD, PhD, will present at ... by H.C. Wainwright & Co) taking place ... Currently, the management team will be ...
(Date:9/2/2015)... Fla. , Sept. 2, 2015   Voalte ... a new capital infusion of $17 million by ... Cerner Corporation, and Bedford Funding. Series D funding closed ... has raised to nearly $60 million in three years. ... sustain a triple-digit growth trajectory for Voalte. The privately ...
Breaking Medicine Technology:Delcath To Present At The 17th Annual Rodman & Renshaw Conference 2Delcath To Present At The 17th Annual Rodman & Renshaw Conference 3CytoSorbents to Present at the 2015 Rodman & Renshaw Annual Global Investment Conference 2CytoSorbents to Present at the 2015 Rodman & Renshaw Annual Global Investment Conference 3CytoSorbents to Present at the 2015 Rodman & Renshaw Annual Global Investment Conference 4Voalte Raises $17 Million in Series D Financing 2Voalte Raises $17 Million in Series D Financing 3Voalte Raises $17 Million in Series D Financing 4
... with the Foundation of UMDNJ and New Jersey Health Foundation, ... $100,000 to fund the research of Dr. Alexey G. Ryazanov, ... Johnson Medical School (RWJMS) and a member of The Cancer ... Research and Development Fund in Pharmacology in the Department of ...
... drug-related poisoning in the United States continue to rise; ... the American Association of Poison Control Centers are raising ... of Poison Prevention Week (March 20-26).   In addition, ... them to continue allocating more than $29 million in ...
Cached Medicine Technology:International Biotech Firm Funds Research Into Aging Through Foundation of UMDNJ 2Drug-Related Poisoning The Cause For Nearly 700,000 Emergency Department Visits a Year, According to New Research 2Drug-Related Poisoning The Cause For Nearly 700,000 Emergency Department Visits a Year, According to New Research 3
(Date:9/2/2015)... ... , ... Every year at this time, students prepare to go back to ... face the academic workload confronting them. They just don’t have the skills needed to ... teach students how to study. , “Bankers bank. Salesmen sell. Teachers teach. The job ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... announces Hand Free Pocket Cop, a safety invention that protects people from crime ... worth $31 billion," says Scott Cooper, CEO and Creative Director of World Patent ...
(Date:9/2/2015)... ... , ... Ovarian cancer continues to be the deadliest of all gynecologic cancers. ... her lifetime is approximately 1 in 75. This year it is estimated that approximately ... , There is no test to detect ovarian cancer. A Pap test does ...
(Date:9/2/2015)... , ... September 02, 2015 , ... ... the pioneer in marine cosmetics introduces PIONNIÈRE XMF Perfection Youth Rich Cream ... cream combines breakthrough biotechnological anti-aging power with a lipid-replenishing marine oil for intense ...
(Date:9/2/2015)... ... September 02, 2015 , ... Canopy Partners, a North Carolina ... Inc. 5000 List, an independent ranking of the fastest- growing private companies ... this achievement puts Canopy in rarefied company. Over the years, this elite group ...
Breaking Medicine News(10 mins):Health News:5 Essential Study Tips Every Student Needs for Academic Success but Schools Do Not Teach 2Health News:5 Essential Study Tips Every Student Needs for Academic Success but Schools Do Not Teach 3Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 2Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 3Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 4Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 5Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 6Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 7Health News:National Ovarian Cancer Coalition's DFW Chapter Features First Annual Teal Lights Display This Friday, September 4th, "National Wear Teal Day" 2Health News:National Ovarian Cancer Coalition's DFW Chapter Features First Annual Teal Lights Display This Friday, September 4th, "National Wear Teal Day" 3Health News:Phytomer announces PIONNIÈRE XMF Perfection Youth Rich Cream 2Health News:Phytomer announces PIONNIÈRE XMF Perfection Youth Rich Cream 3Health News:Phytomer announces PIONNIÈRE XMF Perfection Youth Rich Cream 4Health News:Canopy Partners Named to 2015 Inc. 5000 Fastest Growing Companies List 2
... groups were thought to be rare, but recent studies ... the thin beauty ideal. As a result, experts expect ... ethnic groups. It is also suspected that eating disorders ... boys. Although research has shown that eating disorders ...
... of the Charmin Restrooms to ... Times Square This Holiday Season, NEW YORK, Nov. ... free, fully-staffed public restrooms,in New York City as the Charmin(R) Restrooms ... Shannon will inaugurate the stalls,with the ceremonial "first flush" and ribbon ...
... Family Caregiver,s Month; Announces Availability ... More than 34 Million Caregivers, PALO ALTO, Calif., Nov. ... proud to support the more than 34 million,Americans caring for ... availability of its website. Designed to give caregivers the ...
... Flow Cytometry Portfolio Targeted at Fast Growing ... ... Nov. 19, Beckman Coulter, Inc. (NYSE: BEC ), a leading,developer ... A/S, a world leader in cancer diagnostics,announced today that Beckman Coulter ...
... REDWOOD CITY, Calif., Nov. 19 People grow ... is no different. SleepQuest, the leader in,at-home diagnostic ... growing pains which accompany rapid growth by moving ... INC. Magazine,s 5000 Fastest Growing Private,Companies in America, ...
... GNC is joining St. Jude Children,s,Research Hospital as ... is the fourth year for the national campaign and ... in the effort. Thanks and Giving was created ... Thomas and her siblings, Terre and Tony,Thomas, the children ...
Cached Medicine News:Health News:Eating disorders in adolescents 2Health News:Eating disorders in adolescents 3Health News:Video: Charmin's Gift That Keeps on Giving! 2Health News:Resource to Help Care for Aging Parents Now Available Nationwide 2Health News:Resource to Help Care for Aging Parents Now Available Nationwide 3Health News:Beckman Coulter to Acquire Flow Cytometry Instrumentation Business From Dako 2Health News:Beckman Coulter to Acquire Flow Cytometry Instrumentation Business From Dako 3Health News:SleepQuest Continues Growth, Moves Headquarters 2Health News:GNC Joins St. Jude Children's Research Hospital(R) to Kick Off Fourth Annual Thanks And Giving(R) Campaign, Asking America to Help Save Children's Lives While Shopping for the Holidays 2Health News:GNC Joins St. Jude Children's Research Hospital(R) to Kick Off Fourth Annual Thanks And Giving(R) Campaign, Asking America to Help Save Children's Lives While Shopping for the Holidays 3
Expressions lets you change your eye color with lenses that offer incredible comfort and outstanding vision quality. Expression color lenses use a technologically advanced tinting process to produce ...
Modern, innovative and quick Intense Pulsed Light system. The Flash 1 is light and very compact, thus easily portable. Available in two different colors....
... for the physician who wishes to offer ... of clinical applications. The innovative cooled Nd:YAG ... treaent of deeper lying veins. The IPL ... and pigmented lesions, including IPL Skin Treaents ...
Available in Purple, orange, dark blue, yellow, gray, royal blue, green and light blue colors....
Medicine Products: