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CyberKnife Radiosurgery for Early-Stage Breast Cancer
Date:10/31/2010

rent treatment for early-stage disease while attempting to increase convenience, limit invasiveness, decrease toxicity and improve cosmesis compared to other methods of radiation treatment. The treatment regimen using the CyberKnife System would be five days compared to 25-30 days typically associated with conventional radiation therapy.

"In particular, we believe a very abbreviated, non-invasive, outpatient treatment would be considered a favorable option to underserved populations of women living in more remote areas for whom longer courses of treatment pose a barrier," said Robert Timmerman, M.D., professor of Radiation Oncology at UTSW and lead author of the ongoing study.

(1). Fisher B, Anderson S, Bryant J, Margolese R, Deutsch M, Fisher E, Jeong J-H, Wolmark N.  Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer.  New England Journal of Medicine 2002; 347:1233-1241.

(2). Wadasadawala T, Sarin R, Budrukker A et al. Accelerated partial-breast irradiation vs conventional whole-breast radiotherapy in early breast cancer: A case-control study of disease control, cosmesis, and complications.  Journal of Cancer Research & Therapy 2009: 5:2 93-101.

(3).  Watkins JM, Harper JL, Dragun AE, Ashenafi MS, Sinha D, Li J, Cole DJ, Jenrette JM 3rd. Incidence and prognostic factors for seroma development after MammoSite breast brachytherapy. Brachytherapy. 2008;7:305-9.

(4).  Evans SB, Kaufman SA, Price LL, Cardarelli G, Dipetrillo TA, Wazer DE. Persistent seroma after intraoperative placement of MammoSite for accelerated partial breast irradiation: incidence, pathologic anatomy, and contributing factors. Int J Radiat Oncol Biol Phys. 2006;65:333-9.

(5).  Jagsi R, Ben-David MA, Moran JM, Marsh RB, Griffith KA, Hayman JA, Pierce LJ.  Unacceptable cosmesis in a protocol investigatin
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SOURCE Accuray Incorporated
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