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Cutanea Announces Promising Phase II Results in Rosacea with Omiganan
Date:10/17/2007

tular Rosacea, while oral medications are prescribed for severe disease. Current oral antibiotic therapies may alleviate symptoms of rosacea, but may present an issue with undesirable side effects). While there are other topical products currently available on the market, there is an opportunity to improve the existing irritation profile for these treatments.

About Omiganan

Cutanea Life Sciences licensed the exclusive worldwide rights for dermatological uses to a novel, cationic, antimicrobial peptide, whose active component is omiganan pentahydrochloride from Migenix Inc., a British Columbia Corporation located in Vancouver, BC, Canada (TSX: MGI; OTC: MGIFF). Omiganan is in development as a topical treatment for papulopustular rosacea and may prevent the inflammatory cascade that is theorized to lead to the signs and symptoms of rosacea. Omiganan topical gel has been evaluated in early stage clinical trials at concentrations of 0.5% and 3.0%, and early and late stage trials at 1.0%. At each of these concentrations and in all trials conducted, omiganan was found to be safe, well tolerated and non-irritating with no evidence of systemic absorption. While cationic antimicrobial peptides, such as Omiganan, are well known for their antimicrobial properties, recent research has shown that they also may play a role in the inflammatory response. Omiganan, in in vitro assays, demonstrated a rapid bactericidal activity against microorganisms that colonize the skin and that may play a role in the pathogenesis of inflammatory lesions.

About Cutanea

Cutanea Life Sciences is an emerging specialty pharmaceutical company focused on improving human health and appearance through the development and commercialization of treatments for diseased and aging skin conditions. The Company strives to maximize value through flawless execution of strategically designed programs. Its core strategy is to in-license novel, patented, mid- stage treatment candidates for aggr
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