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Current and Emerging Drugs Have No Advantage Over Enbrel in Inhibiting/Slowing the Progression of Rheumatoid Arthritis
Date:4/7/2008

Although Some Emerging Therapies Hold Promise, Enbrel Will Remain the

Clinical Gold Standard Through 2016, According to a New Report from

Decision Resources

WALTHAM, Mass., April 7, 2008 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms focusing on pharmaceutical and healthcare issues, finds that a drug's effect on inhibiting/slowing the progression of structural damage and reducing the signs and symptoms of rheumatoid arthritis during the first year of treatment are the attributes that most influence surveyed rheumatologists' prescribing decisions in the treatment of the disease. Clinical data and expert opinion shows that current and emerging therapies have no advantage in these attributes over the market sales leader, Amgen/Wyeth/Takeda's Enbrel.

The new report entitled Rheumatoid Arthritis: Competitive, Crowded Market Sets the Bar High for Novel Agents finds that, through 2016, there are no therapies in development that will displace Enbrel as the clinical gold standard treatment for rheumatoid arthritis. While some therapies in development for the disease hold promise, most have efficacy, safety and tolerability, and/or delivery features that are inferior when compared with Enbrel.

The overall efficacy of emerging therapies such as Centocor/Schering-Plough/Mitsubishi Tanabe/Janssen's golimumab and Biogen Idec/Genentech/Roche's ocrelizumab is comparable to that of Enbrel, while the overall safety and tolerability for emerging therapies that include ocrelizumab and UCB's Cimzia are also comparable to that of Enbrel. However, the currently available clinical data for golimumab, ocrelizumab and Cimzia is not as robust or extensive as those available for Enbrel.

"While emerging therapies such as golimumab and Cimzia offer superior delivery to that of Enbrel due to improved dosing frequencies, these agents' overall efficacy, safety and tolerability, respect
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SOURCE Decision Resources, Inc.
Copyright©2008 PR Newswire.
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