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CureFAKtor Pharmaceuticals Receives Orphan Drug Designation for Its Lead Compound CFAK-C4 for the Treatment of Pancreatic Cancer
Date:1/18/2011

lid tumors in that its unique mechanism of action disrupts the signaling of FAK in tumors by targeting specific protein to protein bindings.  Since FAK is over-expressed in virtually all solid tumors, the technology has broad applicability in oncology.

More than 40 compounds have been identified that target FAK signaling sites.  CFAK-C4, discovered by Dr. Elena Kurenova, Ph.D. Associate Professor, Roswell Park Cancer Institute,  Senior Scientist and Co-Founder of CureFAKtor, is the lead product candidate in CureFAKtor's pipeline. In pre-clinical studies, CFAK-C4 demonstrated efficacy in a number of cancers including pancreatic, breast, advanced melanoma and neuroblastoma. The Company's second product candidate, CFAK-Y15, discovered by Dr. Vita Golubovskaya, Ph.D. Associate Professor, Roswell Park Cancer Institute, Senior Scientist and Co-Founder of CureFAKtor, is being investigated for the treatment of breast, pancreatic, neuroblastoma and colon cancer.

CureFAKtor has attracted a renowned Board of Directors which includes David Keiser, Former President and Co-Founder of Alexion Pharmaceuticals, Inc. and Dr. Daniel Kleiner, Surgeon and Clinical Instructor at the University of Virginia.  Scientific Advisory Board members include: Dr. Murray Brennan, Former Chair of Surgery at Memorial Sloan-Kettering Cancer Center; Dr. Edison Tak-Bun Liu, Executive Director of Human Genome Institute of Singapore; and Dr. Alex Adjei, Senior Vice President of Clinical Research and Chair of the Department of Medicine at Roswell Park Cancer Institute.

"Focal Adhesion Kinase protein binding inhibitors represent a promising area of research as FAK is expressed at extremely high levels in solid cancer tumors to serve as a survival mechanism by signaling tumor growth, invasion and metastasis.  Dr. William Cance's groundbreaking work has shown that FAK protects tumors from chemotherapy, radiation and the body's natural defenses," said Dr. H. Shelt
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SOURCE CureFAKtor Pharmaceuticals, LLC
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