Navigation Links
CuraGen and TopoTarget Initiate Phase I/II Clinical Trial of Belinostat (PXD101) Combination Therapy for Acute Myeloid Leukemia
Date:8/28/2007

BRANFORD, Conn., Aug. 28 /PRNewswire-FirstCall/ -- CuraGen Corporation (Nasdaq: CRGN) and TopoTarget A/S (Copenhagen Stock Exchange: TOPO) announced today the initiation of patient dosing in a Phase I/II clinical trial evaluating belinostat (PXD101), a histone deacetylase (HDAC) inhibitor, in combination with the anthracycline idarubicin for the treatment of Acute Myeloid Leukemia (AML). The trial is being conducted at multiple sites in the European Union.

Patients under the age of 60 with relapsed or refractory AML, or patients over 60 with newly diagnosed or previously treated AML, are eligible for enrollment in the trial. Initially, 24 to 40 patients will be enrolled into one of two treatment arms and receive intravenous treatment with a combination of belinostat and idarubicin. Patients will receive standard doses of idarubicin in combination with either belinostat administered intravenously once daily for five days, or a continuous infusion of belinostat over 24 to 48 hours. Enrollment into the arms will occur in parallel in order to assess safety and define the maximum tolerated dose (MTD) for each treatment regimen. Upon establishing the MTD for each treatment arm, the trial will be advanced into Phase II to further define the safety and efficacy of belinostat in combination with standard doses of idarubicin.

Patients demonstrating complete or partial response, as defined by the Revised Recommendations of the International Working Group, will continue to receive treatment with belinostat until disease progression. The primary objectives for the study include safety, tolerability, and efficacy for each treatment regimen. Secondary objectives include time to response, duration of response, and surviva
'/>"/>

SOURCE CuraGen Corporation
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. CuraGen Presents Update on Clinical Development Program for Belinostat
2. CuraGen and TopoTarget Announce New Clinical Results With Belinostat to be Reported at Upcoming Major Medical Meetings
3. CuraGen Announces New Preclinical Results with Belinostat and Velafermin to be Presented at AACR Annual Meeting
4. Malvern initiates European user group meetings for chemical imaging
5. Protalix BioTherapeutics, Inc. Receives Approval from the FDA to Initiate a Phase III Clinical Trial of prGCD
6. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
7. Phase 3 Results for Dabigatran Etexilate, an Investigational Oral Anticoagulant, Presented Today at the XXIst Congress of the International Society on Thrombosis and Haemostasis
8. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
9. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
10. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
11. Actemra (tocilizumab) Third Phase III Study Results Show Significant Improvement in Symptoms of Patients with Rheumatoid Arthritis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/1/2015)... Salix Pharmaceuticals, Ltd. (the " Company " ... Valeant Pharmaceuticals International, Inc. (NYSE: VRX ) (TSX:VRX), ... Fundamental Changes, Make-Whole Fundamental Changes and Merger Event, Fundamental ... and Offer to Purchase (the " Notice ") to ... (the " Notes "), pursuant to the Indenture, dated ...
(Date:4/1/2015)... -- New York College of Health Professions announces a valuable ... U.S. Patent #8,996,098 donated by its Chairman under the ... instrument that allows surgeons to view and compare what ... traditional format of a slide that is used during ... thus providing the surgeon real time analysis and information. ...
(Date:4/1/2015)... , April 1, 2015  Hologic, Inc. (NASDAQ: ... holders of the 2.00% Convertible Exchange Senior Notes due ... and Wilmington Trust Company, the trustee, paying agent and ... to convert the notes.  This conversion right is subject ... notes dated as of December 10, 2007, as supplemented ...
Breaking Medicine Technology:Salix Provides Notice of Fundamental Changes, Make-Whole Fundamental Changes and Merger Event Relating to Its 1.5% Convertible Senior Notes Due 2019 2Salix Provides Notice of Fundamental Changes, Make-Whole Fundamental Changes and Merger Event Relating to Its 1.5% Convertible Senior Notes Due 2019 3Salix Provides Notice of Fundamental Changes, Make-Whole Fundamental Changes and Merger Event Relating to Its 1.5% Convertible Senior Notes Due 2019 4Salix Provides Notice of Fundamental Changes, Make-Whole Fundamental Changes and Merger Event Relating to Its 1.5% Convertible Senior Notes Due 2019 5Salix Provides Notice of Fundamental Changes, Make-Whole Fundamental Changes and Merger Event Relating to Its 1.5% Convertible Senior Notes Due 2019 6Salix Provides Notice of Fundamental Changes, Make-Whole Fundamental Changes and Merger Event Relating to Its 1.5% Convertible Senior Notes Due 2019 7Ground-Breaking Surgical Instrument Allows Surgeons to obtain Real Time Biopsies 2Ground-Breaking Surgical Instrument Allows Surgeons to obtain Real Time Biopsies 3Hologic Delivers Notice that Holders of 2.00% Convertible Exchange Senior Notes Due 2037 are Eligible to Convert 2
... Feb. 19, 2011 Genoptix, Inc. (Nasdaq: ... a memorandum of understanding ("MOU") providing for the settlement ... the Superior Court of the State of California, San ... Genoptix, Inc., Case No. 37-2011-00050762-CU-BT-NC, (2) Schwitters v. Genoptix, ...
... 18, 2011 TLC Vision announced today its plans for ... in San Diego.  Internationally recognized as leaders in field of ... Tanzer MD will lend their surgical skill and expertise to ... center will continue to be at the forefront of working ...
Cached Medicine Technology:Genoptix Enters Into Memorandum of Understanding Related to Class Action Lawsuits 2Genoptix Enters Into Memorandum of Understanding Related to Class Action Lawsuits 3Genoptix Enters Into Memorandum of Understanding Related to Class Action Lawsuits 4Genoptix Enters Into Memorandum of Understanding Related to Class Action Lawsuits 5Genoptix Enters Into Memorandum of Understanding Related to Class Action Lawsuits 6Genoptix Enters Into Memorandum of Understanding Related to Class Action Lawsuits 7Genoptix Enters Into Memorandum of Understanding Related to Class Action Lawsuits 8Genoptix Enters Into Memorandum of Understanding Related to Class Action Lawsuits 9Genoptix Enters Into Memorandum of Understanding Related to Class Action Lawsuits 10Genoptix Enters Into Memorandum of Understanding Related to Class Action Lawsuits 11TLC Vision Announces TLC Laser Eye Center San Diego 2
(Date:4/2/2015)... April 02, 2015 Zapable - a ... with a quick and easy means for creating professional ... week creating a buzz of excitement throughout the Internet ... the attention of HonestyFirstReviews.com’s Tiffany Hendricks, prompting her to ... Andrew and Chris Fox's new Zapable software ...
(Date:4/2/2015)... Miami, FL (PRWEB) April 02, 2015 ... Track and Field gets its start! Runners have been ... are ready to start racing. Zensah®, a premium compression ... to help ensure the athletes are benefiting from ... , Zensah® is a Miami-based company, committed to using ...
(Date:4/2/2015)... April 02, 2015 Grab your favorite latte ... all of the hottest trends with the all-new, half-hour debut ... April 8th at 7:00 AM ET/PT, 6:00 AM CT, and ... queen and marketing and product strategist Forbes Riley, Forbes ... guests as well as entrepreneurs, inventors, and innovators whose creations ...
(Date:4/2/2015)... Memphis, TN: MedixSafe Vanguard 2 is available, a full ... to meet security demands – from stocking a large ... service keeping limited narcotics from falling into the wrong ... with a wireless connection to your network and mobile ... , MedixSafe Vanguard 2 provides tracking narcotics inventory ...
(Date:4/2/2015)... 2015 IDEX Health & Science ... website featuring a simple 3-click path to purchase, ... tools, and informative distributor and customer support. Using ... in fluidics products and engineering, while exceeding customer ... website’s robust product filtering and configuration tools make ...
Breaking Medicine News(10 mins):Health News:Zapable - Review Examining Andrew and Chris Fox’s App Building Software System Released 2Health News:Zensah® Partners With Austin Track Club 2Health News:Zensah® Partners With Austin Track Club 3Health News:Forbes Living Showcases Trendsetters on Discovery Channel Transponder 2Health News:Forbes Living Showcases Trendsetters on Discovery Channel Transponder 3Health News:MedixSafe Introduces New High Tech Narcotics Security Solution - Vanguard 2 2Health News:IDEX Health & Science Launches New Website with 4000+ Products 2Health News:IDEX Health & Science Launches New Website with 4000+ Products 3
... Red Cross preparing for more storms to come, ... communities large and small, Red Cross people and supplies,are ... the devastating,tornadoes which began hitting February 5. In every ... providing shelter, feeding,victims and search and rescue workers, and ...
... Kan., Feb. 6 Mediware Information,Systems (Nasdaq: MEDW ... to,the board of directors. The Company also announced that ... 16 years of valuable,service., Mr. Coelho, age 64, ... technology consumer electronic or medical device companies. He is ...
... HILL, N.C., Feb. 6 From early ... customer feedback has,enhanced services, products and processes ... study by Best Practices, LLC,s Global Benchmarking,Council. ... is key,to better aligning the customer service ...
... Although scientists have speculated over the negative effects of ... environmental toxins may disrupt the normal growth and hormonal ... as the mycoestrogen zearalenone (ZEA) produced by the Fusarium ... have properties similar to the female reproductive hormone estrogen, ...
... 6 Rising Medical Solutions, Inc.,(Rising), a ... the Private Company Index (PCI) "Top Growth ... 2007., (Logo: http://www.newscom.com/cgi-bin/prnh/20080206/AQW030LOGO-b ), ... published by Entrex, Inc. ( http://www.entrex.net ), ...
... Henry Ford Hospital is embarking on an expanded major clinical ... radiation therapy, to determine if the combined treatment is more ... prostate cancer. , The clinical trial is part of a ... to Henry Ford to study the effectiveness of gene therapy ...
Cached Medicine News:Health News:Massive American Red Cross Tornado Relief Effort Spans Five States 2Health News:Philip Coelho Joins Mediware Board 2Health News:Philip Coelho Joins Mediware Board 3Health News:Customer Experience Conference, Feb. 25-27: Sharing New Insights on Winning Customer Loyalty 2Health News:New study suggests link between environmental toxins and early onset puberty in girls 2Health News:Rising Medical Solutions, Inc. Ranks Fifth on the Private Company Index (PCI) 'Top Growth Companies' List 2Health News:Henry Ford Hospital expands research on gene and radiation therapy for prostate cancer 2Health News:Henry Ford Hospital expands research on gene and radiation therapy for prostate cancer 3
CritiCool™ offers precise cooling to the programmed target temperature by applying temperature control algorithm....
Complete Cataract Competence , OPMI VISU 140 is compact, good and economical. It's everything a cataract specialist needs today....
Blood grouping tubes are available in two formulations, ACD-A, ACD-B or with a CPDA solution. Blood grouping tubes are for blood grouping determinations and also for cell preservation....
BD Vacutainer® PST™ Tubes contain spray-coated lithium heparin and a gel for plasma separation. They are used for plasma determinations in chemistry....
Medicine Products: