CuraGen Updates CR011-vcMMAE Da... ( - Activity Demonstrated in Advanced B...)

CuraGen Updates CR011-vcMMAE Data at ASCO

Date:6/2/2009

- Activity Demonstrated in Advanced Breast Cancer and Melanoma -

- Conference call to be hosted Wednesday, June 3, 2009 at 11:00am ET to discuss results -

BRANFORD, Conn., June 2 /PRNewswire-FirstCall/ -- CuraGen Corporation (Nasdaq: CRGN) reported three data presentations from its ongoing clinical trials of CR011-vcMMAE, an antibody-drug conjugate that targets GPNMB, in patients with advanced breast cancer and melanoma at the 2009 Annual Meeting of the American Society of Clinical Oncology (ASCO) in Orlando, Florida.

The Phase I/II study of CR011-vcMMAE administered intravenously once every three weeks in patients with advanced breast cancer began with a bridging phase to confirm the maximum tolerated dose and has expanded into a Phase II open-label, multi-center study. The study is designed to assess efficacy with an endpoint of progression-free rate at 12 weeks. The principal investigator is Dr. Linda Vahdat, Medical Director of the Breast Cancer Research Program and Associate Professor of Clinical Medicine, NewYork-Presbyterian Hospital/Weill Cornell.

Preliminary data were presented on 18 evaluable patients treated at doses of 1.0 - 1.88mg/kg from the Phase I portion and the initial portion of the Phase II study. Selection for enrollment was not based on expression of GPNMB in patients' tumors. The median number of prior chemotherapy regimens for metastatic disease was 4 (range 2-11). Triple negative disease (ER/PR/Her-2 negative) was present in 44% of patients. Partial responses were seen in 3 patients (1 confirmed), including a patient with triple negative disease. Fifty percent (50%) of patients showed tumor shrinkage. Toxicities were similar to those observed in previous studies with CR011-vcMMAE; the most common adverse events were rash, alopecia, and fatigue. Twe
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Related medicine technology :

1. CuraGen to Present CR011-vcMMAE Data at ASCO
2. CuraGen Announces Preliminary Data from Ongoing Phase II Study Showing Clinical Activity of CR011-vcMMAE in Patients with Metastatic Melanoma
3. CuraGen to Host Conference Call and Webcast to Discuss Third Quarter 2008 Financial Results and CR011-vcMMAE Phase II Trial Results on November 3, 2008
4. CuraGen Completes Enrollment in Phase II Trial of CR011-vcMMAE in Metastatic Melanoma
5. CuraGen Reports Second Quarter 2008 Financial Results and Clinical Progress of CR011-vcMMAE
6. CuraGen Announces Initiation of Phase II Trial of CR011-vcMMAE in Patients with Advanced Breast Cancer
7. CuraGen Announces Expansion of CR011-vcMMAE Phase II Trial in Melanoma
8. CuraGen Announces Data From Ongoing Phase I/II Trial Showing Clinical Activity of CR011-vcMMAE in Metastatic Melanoma
9. CuraGen Advances CR011-vcMMAE into Phase II
10. CuraGen and TopoTarget Announce Presentations on Belinostat at the Upcoming American Society of Hematology 49th Annual Meeting
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