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CuraGen Announces Top-Line Phase II Results on Velafermin
Date:10/11/2007

patients at 33 centers in the United States. Patients enrolled in the trial were randomized to receive a single infusion of either placebo or one of three dose levels of velafermin (10 mcg/kg, 30 mcg/kg or 60 mcg/kg) administered 24 hours after BMT.

The primary endpoint was a decrease in the incidence of severe oral mucositis in patients receiving 30 mcg/kg velafermin compared to placebo. Secondary endpoints evaluated included duration of oral mucositis, patient self-reported pain score, use of pain medications, the incidence and duration of febrile neutropenia, and use of enteral or parenteral nutrition.

The complete results from CLN-12 will be presented in December at the American Society of Hematology (ASH) 2007 Annual Meeting in Atlanta, GA.

CuraGen will host a conference call today at 8:30 a.m. Eastern Time. Dial-in and webcast information are provided below.

Dial-in and Webcast Information

Date: Thursday, October 11, 2007

Time: 8:30 a.m. EDT

Dial-in: 877-272-5391 (domestic)

706-758-4315 (international)

Passcode: 20509852

Webcast: Access to the live webcast is available at

http://www.curagen.com.

A replay of the conference call will be available starting at 12:00 p.m. Eastern time on Thursday, October 11, 2007 through Sunday, November 11, 2007 by dialing 800-642-1687 (domestic) or 706-645-9291 (international). The passcode for the replay is 20509852. An archive of the webcast will be available for 30 days at http://www.curagen.com.

Pipeline Update

Upcoming Presentations at the AACR-NCI-EORTC 2007 International Conference on Molecular Targets and Cancer Therapeutics, October 22-26, 2007, in San Francisco, CA:

Belinostat

Title: Phase II Multicenter Trial of Belinostat (PXD101) i
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SOURCE CuraGen Corporation
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