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CuraGen Announces Presentation of Phase I Dose-Escalation Results on CR011- vcMMAE for Metastatic Melanoma
Date:10/24/2007

h Stage III or Stage IV malignant melanoma.

"We are encouraged by these initial clinical results on CR011-vcMMAE and the suggestion of potential anti-cancer activity in patients with previously progressive disease, which support continued evaluation of this antibody-drug conjugate in the treatment of advanced melanoma. We continue to enroll patients into the trial, and look forward to further characterizing the activity of this novel therapeutic," commented Dr. Mario Sznol, co-Principal Investigator, Co-Director of the Melanoma Program at the Yale Cancer Center in New Haven, CT.

This open-label, dose-escalation study conducted at the Yale Cancer Center, New Haven, CT, MD Anderson Cancer Center, Houston, TX, and The Angeles Clinic and Research Institute, Santa Monica, CA, is evaluating the safety, tolerability and pharmacokinetics of CR011-vcMMAE for patients with unresectable Stage III or Stage IV melanoma who have failed no more than one prior line of cytotoxic therapy. The first part of the trial will evaluate cohorts of patients receiving increasing doses of CR011-vcMMAE to determine the MTD. After determination of the MTD, up to approximately 32 additional patients will be enrolled and treated at the MTD to further define the safety and efficacy of CR011-vcMMAE.

CuraGen will host a conference call on Thursday, October 25, 2007 at 5:00 p.m. Eastern time to discuss these Phase I results on CR011-vcMMAE and the four posters discussing Phase I and Phase II clinical trial results with belinostat being presented at the AACR-NCI-EORTC International Conference.

Conference Call Details and Dial-in Information

Date: Thursday, October 25, 2007

Time: 5:00 p.m. Eastern time

Dial-in: 877-272-5391 (domestic)

706-758-4315 (international)

Passcode: 21928842

Webcast: Access to the live webcast and presentation are available at


SOURCE CuraGen Corporation
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