Navigation Links
CuraGen Announces Initiation of Phase II Trial of CR011-vcMMAE in Patients with Advanced Breast Cancer
Date:6/25/2008

BRANFORD, Conn., June 25 /PRNewswire-FirstCall/ -- CuraGen Corporation (Nasdaq: CRGN), a clinical-stage biopharmaceutical company focused on oncology, announced today the treatment of the first patient in its CR011-vcMMAE Phase II breast cancer study.

The Phase II trial is an open-label, multi-center study of CR011-vcMMAE administered intravenously once every three weeks to patients with locally-advanced or metastatic breast cancer who have received prior therapy. This study will enroll up to approximately 40 patients to confirm the maximum tolerated dose (MTD) in this population and to assess efficacy using a Simon 2-Stage design with an endpoint of progression-free rate at 12 weeks. The principal investigator is Dr. Linda Vahdat, Medical Director of the Breast Cancer Research Program and Associate Professor of Clinical Medicine, NewYork-Presbyterian Hospital/Weill Cornell.

"We believe that GPNMB is a promising target in breast cancer, and we look forward to better understanding how CR011-vcMMAE could be used in the treatment of this disease," commented Dr. Timothy Shannon, President and Chief Executive Officer of CuraGen Corporation. "We are confident in our ability to continue the rapid development of this program and look forward to providing updated CR011-vcMMAE results for the treatment of melanoma by the end of 2008 and the presentation of preliminary results from this newly initiated study in breast cancer during the first half of 2009."

CR011-vcMMAE targets a protein known as glycoprotein NMB (GPNMB), which is overexpressed in a variety of cancers including breast cancer, melanoma, and brain tumors. CR011-vcMMAE is an antibody-drug conjugate comprised of a fully-human monoclonal antibody against GPNMB linked
'/>"/>

SOURCE CuraGen Corporation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. CuraGen Provides Update on Velafermin, Belinostat and CR011-vcMMAE Clinical Development Programs
2. CuraGen and TopoTarget Initiate Phase I/II Clinical Trial of Belinostat (PXD101) Combination Therapy for Acute Myeloid Leukemia
3. CuraGen Announces Top-Line Phase II Results on Velafermin
4. CuraGen Announces Presentation of Phase I Dose-Escalation Results on CR011- vcMMAE for Metastatic Melanoma
5. CuraGen and TopoTarget Announce Presentation of Belinostat Clinical Trial Results at AACR-NCI-EORTC International Conference
6. CuraGen and TopoTarget Announce Presentations on Belinostat at the Upcoming American Society of Hematology 49th Annual Meeting
7. CuraGen Advances CR011-vcMMAE into Phase II
8. CuraGen Announces Data From Ongoing Phase I/II Trial Showing Clinical Activity of CR011-vcMMAE in Metastatic Melanoma
9. CuraGen Announces Expansion of CR011-vcMMAE Phase II Trial in Melanoma
10. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
11. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)...  Tandem Diabetes Care ® , Inc. (NASDAQ: ... and manufacturer of the t:slim ® Insulin ... non-profit dedicated to improving diabetes therapy management by ... diabetes data accessibility. This partnership will enable users ... development, to download and access data from their ...
(Date:11/21/2014)... , Nov. 21, 2014  World Hemp Oil, ... low THC, announces they are now offering legal, organic ... Charlotte,s Web type strains grown in medical marijuana states. ... neurological disorders, such as Parkinson,s, MS, and spinal cord ... laws to pass, because imported CBD Oil Is legal ...
(Date:11/21/2014)... SOUTH PLAINFIELD, N.J. , Nov. 21, 2014  PTC ... announce that the 2014 Legend of Technology Award for Vision, ... Peltz , Ph.D., Chief Executive Officer. This award recognizes an ... industry in New Jersey for several ... Legend of Technology Award," stated Stuart Peltz , Ph.D., ...
Breaking Medicine Technology:Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 2Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 3New CBD Oil From Industrial Hemp is Comparable to Charlotte's Web, Legal In All 50 States 2New CBD Oil From Industrial Hemp is Comparable to Charlotte's Web, Legal In All 50 States 3PTC Therapeutics Announces CEO, Dr. Stuart Peltz Recipient of The New Jersey Technology Council's 2014 Legend of Technology Award 2PTC Therapeutics Announces CEO, Dr. Stuart Peltz Recipient of The New Jersey Technology Council's 2014 Legend of Technology Award 3
... prostate and ... colorectal cancer trials -, SOUTH SAN FRANCISCO, Calif., ... company focused,on oncology, today provided an update of its picoplatin development ... prostate cancer (HRPC), and its oral formulation in solid,tumors. Presenting at ...
... Also This Month: Lessons Learned from the Avandia ... older,adults with diabetes live longer when they are ... December issue of Diabetes Care, which,publishes on November ... is an editorial by U.S. Food and Drug,Administration ...
Cached Medicine Technology:Poniard Pharmaceuticals Provides Year-End Clinical Update at 2007 Lazard Capital Markets Healthcare Conference 2Poniard Pharmaceuticals Provides Year-End Clinical Update at 2007 Lazard Capital Markets Healthcare Conference 3Poniard Pharmaceuticals Provides Year-End Clinical Update at 2007 Lazard Capital Markets Healthcare Conference 4Poniard Pharmaceuticals Provides Year-End Clinical Update at 2007 Lazard Capital Markets Healthcare Conference 5Treating Depression Prolongs Life for Older People with Diabetes 2
(Date:11/23/2014)... Columbus, OH (PRWEB) November 23, 2014 ... Schulte LLC on behalf of farmers and agribusinesses that ... Inc.’s attempts to commercialize Agrisure Viptera and Agrisure Duracade, ... have not been approved for sale in China. According ... caused China to virtually ban U.S. corn imports. Because ...
(Date:11/23/2014)... 2014 BambooFlooringChina.com , the world’s leader ... strand woven bamboo flooring collection. Now, the business is ... company’s CEO, the promotion is valid until Dec. 20, 2014. ... a smooth and dust-free surface, which makes it very easy ... industry, the company wants to make its website the best ...
(Date:11/22/2014)... SC (PRWEB) November 23, 2014 Every ... to their communities. AlignLife experience rapid growth in the ... a very unique opportunity. AlignLife of Simpsonville ... AlignLife offices for their first annual Toy Drive. These ... charity they would support with this year's toy drive. ...
(Date:11/22/2014)... 2014 Cancer researchers in New York ... intercellular communication tunnels and the growth and spread of ... on the Surviving Mesothelioma website. , Doctors ... of Minnesota have just released their study on tunneling ... between cells. They found that mesothelioma cells ...
(Date:11/22/2014)... Recently, UWDress.com, a successful wedding dress shop, ... attire in order to prepare for the wedding season. ... 70% off. , UWDress.com is a reliable company that ... especially the new items -- formal wedding guest attire. This ... market, including superstar and princess. As one of the leading ...
Breaking Medicine News(10 mins):Health News:Syngenta Lawsuits Being Investigated by Wright & Schulte LLC, Following China’s Rejection of Corn Shipments Tainted with Unapproved GMO Seed 2Health News:Syngenta Lawsuits Being Investigated by Wright & Schulte LLC, Following China’s Rejection of Corn Shipments Tainted with Unapproved GMO Seed 3Health News:Click Strand Woven Bamboo Flooring From Famous Bamboo Flooring Company BambooFlooringChina.com 2Health News:Greenville Area AlignLife Offices Join Together for a Local Toy Drive 2Health News:Study Links Cellular ‘Tunnels’ to Mesothelioma Proliferation, According to Surviving Mesothelioma 2Health News:Formal Wedding Guest Attire Added to UWDress.com 2
... Research Group (MRG) has conducted a detailed analysis of ... for Aesthetics Lasers and Energy Devices 2007 report. ... more women will be receiving cellulite reduction procedures as ... In 2006, 330,000 people in the US received laser ...
... Brain holds clue to understand, diagnose and treat bipolar ... International Conference on Bipolar Disorder.It has ... and treatment of the disease. ,The first ... the Laboratory of Molecular Pathophysiology at the National Institute ...
... Scientists from the University of Bonn have discovered this ... have implications for therapy. In animal experiments, a solution ... reactions of the skin. ,Extracts of the ... remedy against inflammation. At the beginning of the last ...
... Pharmaceutical Research & Development, L.L.C., (J&JPRD) announced that ... to the United States Food and Drug Administration ... for the treatment of nosocomial pneumonia, a pneumonia ... healthcare setting. ,According to the Centers ...
... Jordan a.k.a., Katie Price wants to 'tighten up' her vagina after her ... birth to her daughter this month and is firm to have ... I'm a very small girl and my first son Harvey was a ... suffer from a prolapsed womb after they've had a baby. ...
... developer and manufacturer announced today that over 200 ... the OrthoGlide Medial Knee implant. The OrthoGlide is a ... due to moderate osteoarthritis of the medial compartment of ... increase in the number of orthopedic surgeons interested in ...
Cached Medicine News:Health News:Eliminating Cellulite 2Health News:Novel Markers for the Treatment of Bipolar Disorder 2Health News:Cannabinoids Regulate Inflammation Process 2Health News:Cannabinoids Regulate Inflammation Process 3
Rapid Test Kit...
... (Nidek Advanced Vision Information System) is an ... software on a platform designed to communicate ... The network can be expanded in various ... to Nidek products but also to fundus ...
... OcuLight family of infrared laser photocoagulators includes ... These diode lasers serve as a single ... applications, require no regular maintenance or special ... compact design. The OcuLight SLx is now ...
The simplest, most accurate Ortho-K lens fitting system ever!...
Medicine Products: