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Correction: Lilly Presents Data on Cixutumumab in Five Subtypes of Sarcomas
Date:5/27/2011

INDIANAPOLIS, May 27, 2011 /PRNewswire/ -- In the press release, "Lilly Presents Data on Cixutumumab in Five Subtypes of Sarcomas," issued May 19, 2011, by Eli Lilly and Company (NYSE: LLY), the following sentence has been amended to: The best overall responses were as follows:  one partial response in the Ewing sarcoma tier (n=1); and no partial responses, but stable disease of 41 percent (n=9) in leiomyosarcoma; 35 percent (n=6) in synovial sarcoma; 28 percent (n=5) in Ewing family of tumors and 24 percent (n=4) in rhabdomyosarcoma. Complete, corrected text follows.

Eli Lilly and Company (NYSE: LLY) announced data from its Phase II study with cixutumumab in five subtypes of sarcoma, a cancer that develops from connective tissues in the body.  Study results demonstrated that 57 percent of patients with a soft tissue sarcoma known as adipocytic sarcoma (a rare tumor that develops from fat cells) experienced stable disease.  Results from the Phase II study will be presented on Monday, June 6 at 4:15 p.m. CDT during the Sarcoma Oral Abstract Session (Abstract #10004) at the 47th Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago, Ill.

Cixutumumab is a monoclonal antibody that targets the insulin-like growth factor-1 (IGF-1) receptor.  The IGF pathway plays a major role in cancer cell proliferation, survival and resistance to therapy.(1)  Soft tissue sarcomas and the related Ewing family of tumors both have an overabundance of IGF-1 receptors on their surface.  Preclinical and clinical studies have demonstrated that blocking the IGF-1 receptor may prevent IGF-1 signaling and therefore cancer growth.(2,3)  

This trial assessed progression-free survival as a primary endpoint in 113 patients with advanced or metastatic s
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