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Cordex Signs European Development Partnership for ATPotent(TM) Sperm Motility Drug
Date:6/22/2009

ia and the University of Padua, which have shown that in vitro ATP treatment of poorly motile human sperm resulted in improved motility parameters and increased frequency of hyperactivated sperm. The improved motility parameters were also observed in human sperm derived from males with asthenozoospermia and in thawed cryopreserved human sperm.

Results from these published studies support earlier observations from a non-Cordex sponsored European study in which increased success rate of IVF procedures were observed when ATP-treated sperm derived from infertile males with asthenozoospermia were used.

"We are pleased to enter this agreement with CTI as we feel it will accelerate the development of ATPotent(TM) as a novel treatment for the majority of male infertility cases in the United States and other parts of the world," said James S. Kuo, M.D., M.B.A., Cordex's Chairman and CEO. "CTI has the experience, expertise, and track record of obtaining EU regulatory approval for medical products originally developed in the US and marketing them there," he added. "Data obtained by CTI in its clinical trial are expected to support Cordex's efforts to seek marketing approval for ATPotent(TM) from the FDA," said Amir Pelleg, Ph.D., Cordex's President and CSO.

About ATPotent(TM)

ATPotent(TM) is Cordex's novel and proprietary drug candidate for the in vitro treatment of human and animal sperm, in which the active ingredient is adenosine 5'-triphosphate (ATP). ATP is a ubiquitous purine nucleotide found in every cell of the human body where it plays a critical role in cellular metabolism and constitutes the source of energy for all bodily functions. ATP is released from cells under physiologic and pathophysiologic conditions; extracellular ATP acts as a local physiologic regulator by activating cell surface receptors called P2 receptors. Extracellular ATP plays an important role in sperm maturatio
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SOURCE Cordex Pharma, Inc.
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