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Cordex Signs European Development Partnership for ATPotent(TM) Sperm Motility Drug
Date:6/22/2009

Technology Intended to Improve Outcome of Intrauterine Insemination and In Vitro Fertilization Procedures

LA JOLLA, Calif., June 22 /PRNewswire-FirstCall/ -- Cordex Pharma, Inc. (OTC Bulletin Board: CDXP) announced today that it has entered into an agreement with Clinical Trials International, LLC, (CTI), regarding a license to develop and market Cordex's drug candidate, ATPotent(TM).

ATPotent(TM) is a novel ATP-based drug candidate designed for in vitro (outside of the human body) treatment of sperm in conjunction with intrauterine insemination (IUI) and in vitro fertilization (IVF) procedures. ATPotent(TM) is based on Cordex's proprietary technologies related to the use of adenosine 5'-triphosphate (ATP) for improving human and animal sperm motility and fertilization capacity.

According to the agreement, CTI has obtained exclusive rights for the clinical development and marketing of ATPotent(TM) in the European Union (EU) as well as Russia and Ukraine. CTI intends to initiate with Cordex's scientific support a proof-of-concept clinical trial in Italy later this year, the end-point of which is expected to be increased pregnancy rate in IUI procedures prescribed for couples with male infertility due to asthenozoospermia (i.e., low or lack of sperm motility). Cordex will have access to the clinical data to be obtained in this study to support the development of ATPotent(TM) in the rest of the world.

Male factor infertility is implicated in about half of the six million infertile couples in the United States. Lack of, or low sperm motility or movement, is a common cause of human male infertility. It has been reported in the medical literature that the prevalence of asthenozoospermia in infertile men is approximately 82 percent. Currently, there is no FDA-approved drug that enhances sperm motility.

Cordex has sponsored studies at the University of Pennsylvan
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SOURCE Cordex Pharma, Inc.
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