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CorMatrix Announces Publication of Pre-Clinical Data in Journal of American College of Cardiology (JACC) Demonstrating the Role of CorMatrix ECM(TM) Technology in Remodeling Cardiac Tissue
Date:3/16/2010

ngiogenesis.(1-2)
  • Consistent with the time course of SCF expression was an observed increase in the number of c-kit positive cells found in the region injected with the ECM emulsion. c-kit is a well-known molecular marker for bone marrow-derived stem cells.
  • New blood vessel formation in the ECM emulsion treated area was significantly enhanced relative to the control, as evidenced by increased density of alpha-smooth muscle actin (SMA) positive blood vessels.
  • Consistent with enhanced angiogenesis, the ECM emulsion promoted infiltration and sustained accumulation of alpha-SMA expressing myofibroblasts and macrophages, whereas the accumulation of myofibroblasts declined after day seven in the control animals. Increased levels of VEGF protein expression and immunoreactivity were also observed.
  • The wall thickness of the infarcted middle-anterior septum in the area of ECM emulsion injection was significantly increased relative to the control. Echocardiography showed significant improvements in fractional shortening, ejection fraction and stroke volume in the ECM emulsion group.
  • The authors conclude that the data provides direct evidence that adverse cardiac remodeling can be modified by supplying CorMatrix ECM emulsion to the affected myocardium following myocardial infarction.

  • "The results of this study are exciting and suggest that our ECM Technology, when delivered as an injectable form directly into damaged cardiac muscle, delivers results consistent to those observed from implantation of the sheet form of the product that is currently in commercial use for surgical repairs of the human heart," said Beecher Lewis, President and COO of CorMatrix. "
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    SOURCE CorMatrix Cardiovascular, Inc.
    Copyright©2010 PR Newswire.
    All rights reserved

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