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CorMatrix Announces Publication of Pre-Clinical Data in Journal of American College of Cardiology (JACC) Demonstrating the Role of CorMatrix ECM(TM) Technology in Remodeling Cardiac Tissue
Date:3/16/2010

and previous work that we've done show that the adjacent healthy tissue is capable of supplying the correct cells and other factors needed for all phases of tissue reconstruction and regeneration. To do their work, the tissue cells simply need a physiologically correct, biologically supportive microenvironment, which our unique ECM Technology provides."

In the study, the heart muscle damage was caused by delivery of 45 minutes of reversible coronary occlusion. CorMatrix ECM emulsion or saline control was then injected into the affected ischemic myocardium. After three, seven, 21 and 42 days of reperfusion, the affected areas were analyzed for histological and molecular markers of cardiac remodeling, cellular recruitment and cardiac function.

Key Study Findings and Conclusions

  • Expression of stem cell factor (SCF) was significantly increased in damaged heart tissue injected with ECM emulsion, and remained elevated throughout the study compared to the control. SCF has been previously reported to enhance endogenous cardiac repair by recruiting bone marrow-derived stem cells and other differentiated precursor cells, modulating stem cell differentiation, and stimulating expression of vascular endothelial growth factor (VEGF), a key regulator of a
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SOURCE CorMatrix Cardiovascular, Inc.
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