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CorMatrix(R) Announces Intramyocardial Injection of Emulsified ECM Technology(TM) Demonstrates Enhanced Angiogenesis and Improved Cardiac Function in a Preclinical Model
Date:4/1/2008

ardiography showed statistical improvements in end-systolic volume (0.3 +/- 0.1 vs. 0.6 +/- 0.3 ml), fractional shortening (33 +/- 5 vs. 24 +/- 6%) and ejection fraction (67 +/- 6 vs. 53 +/- 10%). The wall thickness of the infarcted middle anterior septum in the injected group was also statistically greater than that in the control (0.19 +/- 0.02 vs. 0.15 +/- 0.02cm).

"This data demonstrates the unique potential of the extracellular matrix material in cardiac applications," said Beecher Lewis, President and COO of CorMatrix. "We are very excited about the results of this study and will continue to evaluate the broad potential utility of our patented ECM Technology."

Currently, the Company's platform ECM Technology is U.S. Food and Drug Administration (FDA) cleared and in use for pericardial closure. The Company is researching a variety of cardiovascular applications using the patented ECM Technology.

About Extracellular Matrix Biomaterial

The unique properties of extracellular matrix biomaterials were discovered at Purdue University. The decellularized matrix material serves as a scaffold to allow adjacent tissues to deliver cells and nutrients to the matrix, which then differentiate into tissue-specific cells. The ECM material is gradually replaced, as the patient's own body reinforces and rebuilds the weakened site. During the repair, the matrix is rapidly degraded and resorbed, leaving remodeled functional tissue where scar tissue or injured tissue would normally be expected.

The use of extracellular matrix materials in non-cardiovascular applications has established a significant foothold in soft tissue repair, wound management and orthopedic applications. The safety of extracellular matrices has been well established in a number of different clinical applications. The extracellular matrix has been studied extensively, with more than 500 published papers. Since 1999, an estimated 500,000 patients worldwide have received an extr
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SOURCE CorMatrix Cardiovascular, Inc.
Copyright©2008 PR Newswire.
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