Navigation Links
Convergence Pharmaceuticals Announces Successful Interim Data from Ground-Breaking Phase II Trigeminal Neuralgia Study
Date:3/27/2013

CAMBRIDGE, England, March 27, 2013 /PRNewswire/ --

Novel sodium channel blocker with excellent pharmacokinetic and safety profile could fill treatment gap for severe pain condition

Convergence Pharmaceuticals Limited ("Convergence"), the company focused on the development of novel analgesic medicines for the treatment of chronic pain, today announces positive interim data from the ongoing Phase II clinical trial of novel sodium channel blocker CNV1014802 in patients with trigeminal neuralgia (TN), a very severe form of facial pain.

CNV1014802 is a novel small molecule state-dependent sodium channel blocker that exhibits potency and selectivity against the Nav 1.7 sodium channel. The Phase II study utilises a novel design, whereby eligible patients are entered into a 3-week open-label treatment period with CNV1014802 at a dose of 150mg three times a day (tid). If a successful response is observed in the final week of this period, patients are then randomised to a 4-week double-blind treatment period with either CNV1014802 150mg tid or placebo.

A planned interim analysis was performed once a pre-defined number of patients had completed the 3-week open-label treatment period. Success criteria for individual patient response was defined as a 30% or more reduction in numbers of paroxysms, or severity of paroxysms, relative to the run-in period. A total of 70% patients showed a successful response and were subsequently randomised into the double-blind treatment period. CNV1014802 was well tolerated in these patients. A Data Monitoring Committee (including medical experts in the treatment of trigeminal neuralgia) reviewed all available efficacy and safety data from the open-label treatment period and agreed that the study should continue to completion as defined in the protocol, using the dose regimen of 150mg tid for CNV1014802.

TN is a very severe form of facial pain that is experienced in short bursts or at
'/>"/>

SOURCE Convergence Pharmaceuticals Ltd
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Eighth Annual WLSA Convergence Summit Focuses on Moving from Innovation to Adoption
2. Pharmaceuticals - Scandinavia Industry Guide
3. RoundTable Healthcare Partners and Argon Medical Devices to Acquire Angiotech Pharmaceuticals Interventional Products Business
4. First Patients Dosed in Proof-of-Concept Clinical Study of Alder Biopharmaceuticals Lead Therapeutic Candidate for Treatment of Migraine, ALD403
5. Valeant Pharmaceuticals International, Inc. Agrees to Acquire Obagi Medical Products, Inc. for $19.75 Per Share in Cash
6. Tech Coast Angels Contributes More Than $3 Million to $16 Million Savara Pharmaceuticals Series B
7. Harwood Feffer LLP Announces Investigation of Spectrum Pharmaceuticals, Inc.
8. Star Scientific and Rock Creek Pharmaceuticals Report on the Beneficial Nutritional Effects of Anatabine in an Animal Model of Ulcerative Colitis
9. Inovio Pharmaceuticals Reports 2012 Fourth Quarter and Year End Financial Results
10. Cadence Pharmaceuticals Appoints Stephen L. Newman, M.D., to its Board of Directors
11. Isis Pharmaceuticals to Host Investor Event to Discuss ISIS-SMN Rx Data Presented at 2013 AAN Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2014)... HARRISBURG, Pa. , Jan. 14, 2014 Dynamic Healthcare ... ("GMH"), announced today that it acquired Progressive Home Medical Equipment, ... January 7, 2014. The terms of the acquisition were not ... medical equipment ("DME") company providing a wide range of sleep, ...
(Date:1/14/2014)... , Jan. 14, 2014 Animal Emergency Critical Care, a ... Leesburg, Virginia is the first in ... chamber. Dr. Susan M. Barnes , Medical ... Barnes and husband, Dr. Cole Taylor , are avid scuba ...
(Date:1/14/2014)... , Jan. 14, 2014 NineSigma , ... hold its Innovation Leadership Summit , May 14-16, ... Cleveland Ohio . ... and organizations committed to breakthrough achievements through open innovation. ...
Breaking Medicine Technology:Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... Calif., Sept. 16, 2011 Accuray Incorporated (Nasdaq: ... its management is scheduled to present at the UBS Global ... 2011 at 4:30 p.m. ET/1:30 p.m. PT. A ... the investor relations page of the Company,s Web site at ...
... Unilife Corporation ("Unilife" or "Company") (NASDAQ: UNIS, ASX: UNS), today ... Global Life Sciences Conference in New York City. Alan Shortall, ... 1:00 p.m. EDT on Monday, September 19, 2011 (Tuesday, ... conference presentation will be broadcast over the Internet as a ...
Cached Medicine Technology:Unilife to Present at the 2011 UBS Global Life Sciences Conference in New York City 2
(Date:4/22/2014)... (SALT LAKE CITY)A computational tool developed at the University ... with unknown gene mutations in three separate cases, U ... new study in The American Journal of Human ... Re-ranking tool), identifies undiagnosed illnesses and unknown gene mutations ... proteins that code for genes are made, in individual ...
(Date:4/22/2014)... available in German . ... the University of Vienna and the Medical University of Vienna, ... how double stranded RNA, such as viral genetic information, is ... immune response against viral infection, the protein ADAR1 moves from ... viral RNA to inhibit reproduction of the virus. But how ...
(Date:4/22/2014)... be influenced by low exposure to testosterone in the ... how men,s testosterone levels may be determined before they ... of the hormone than others is important because testosterone ... the hormone have been linked to obesity, diabetes and ... responsible for producing testosterone in adults known as ...
(Date:4/22/2014)... most of us have gotten stuck in a check-out ... Will Mather, assistant professor of physics and an instructor ... lines, or queues, has been crucial in trying to ... recycling of proteins. , The work, submitted during Mather,s ... from the National Science Foundation in the form of ...
(Date:4/22/2014)... of Calgary,s Hotchkiss Brain Institute (HBI) uncovers a mechanism ... means to restore connections after injury. Dr. Doug Zochodne ... directly regulates nerve cell growth in the damaged nervous ... Nature Communications , with lead authors Drs. Kim ... surprising discovery that a protein called Retinoblastoma (Rb) is ...
Breaking Medicine News(10 mins):Health News:Applying math to biology: Software identifies disease-causing mutations in undiagnosed illnesses 2Health News:Applying math to biology: Software identifies disease-causing mutations in undiagnosed illnesses 3Health News:How the body fights against viruses 2Health News:How the body fights against viruses 3Health News:Queuing theory helps physicist understand protein recycling 2Health News:Scientists discover a new way to enhance nerve growth following injury 2
... the hepatobiliary system is blocked bile ducts. However, artificial ... are medical implants which reopen narrowed bile ducts to ... catheters forming dense communities, so-called biofilms. Inside these biofilms, ... initiated by the host but also from antibiotics. ...
... New research presented at the 17th European Congress ... Plate(R) vibration plate exercise machines in conjunction with a ... harmful belly fat. The study(i), conducted at the University ... who regularly undertook Power Plate(R) exercise were more successful ...
... Institute recognized five hospitals and health systems with Shining Star ... made significant contributions that ultimately make a positive impact on the ... Baylor Health Care System in Dallas, TX, ... vendors. , Meridian Health ...
... to better treatments, scientists say , , SUNDAY, May 10 ... what researchers describe as a treasure trove of genes ... swoop, to find so many genes related to blood ... of one of the studies, Dr. Christopher Newton-Cheh, an ...
... 11 Covance Inc. (NYSE: CVD ) today ... Conference on Tuesday, May 12, 2009 at 4:40 p.m. (ET). ... at www.covance.com . In order to ... minutes early.Covance, with headquarters in Princeton, New Jersey, is one ...
... IDM Pharma, Inc. (Nasdaq: IDMI ) today ... Financial information presented represents the consolidated results of IDM ... and cash equivalents was $7.4 million as of March 31, ... In order to focus on those areas we believe can ...
Cached Medicine News:Health News:Thus the bile does not overflow 2Health News:New Study Finds Power Plate(R) Exercise Aids in Weight Loss, Reduction of Harmful Visceral Fat 2Health News:Five Healthcare Organizations Honored as 'Shining Stars' by The Beryl Institute 2Health News:Genes Yield Clues to High Blood Pressure 2Health News:Genes Yield Clues to High Blood Pressure 3Health News:IDM Pharma Reports First Quarter Financial Results 2Health News:IDM Pharma Reports First Quarter Financial Results 3Health News:IDM Pharma Reports First Quarter Financial Results 4Health News:IDM Pharma Reports First Quarter Financial Results 5Health News:IDM Pharma Reports First Quarter Financial Results 6Health News:IDM Pharma Reports First Quarter Financial Results 7
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: