Navigation Links
Controversy About Lack of Placebo Group Decline in Alzheimer's Clinical Trials
Date:7/28/2008

said. "Based on our analysis, the most reliable approach to maximize the likelihood for demonstrating efficacy is to have a placebo group size greater than 200 and to use the ADAS-cog at least four times and in English."

Scientific Review of Donepezil Trials Shows Slowing Rates of Placebo Group Decline

Professor Roy Jones, Director of RICE -- The Research Institute for the Care of Older People, based at the Royal United Hospital in Bath, England, and colleagues conducted a meta-analysis using individual patient data from randomized, double-blind, placebo-controlled studies of donepezil (Aricept) for Alzheimer's between 1990 and 1999. The work stemmed from discussions and analyses undertaken through an expert working group initiated and funded by Eisai and Pfizer, makers and marketers of donepezil.

"Our results indicate that patients with Alzheimer's entering the later clinical trials appear to be experiencing a slower rate of decline in memory and thinking processes," Jones said. "These observations are potentially important for the future design of clinical trials in people with Alzheimer's. For example, it may be necessary to conduct longer duration research studies -- more than 24 weeks -- to ensure any effects of treatment can be fully evaluated."

Data were available from 3,403 patients who participated in 13 randomized, double-blind, placebo-controlled Alzheimer trials. Data were grouped according to the year of initiation of the trials. Group 1: studies initiated in 1990-1994; Group 2: studies initiated in 1996-1999. This cut-off was associated with the timing of donepezil registration. Changes from baseline MMSE and ADAS-cog scores up to week 24 were compared between groups 1 and 2 for placebo only, and then between donepezil and placebo.

Decline on the MMSE from baseline to week 24 was significantly greater among placebo patients in group 1 (-1.28 points) compared with group 2 (-0.56 points; P = 0.024). Placebo decline on
'/>"/>

SOURCE Alzheimer's Association
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Use it or Lose it: A New Theory About Preserving Erectile Function After Prostate Surgery
2. Bonnie Blair to Break the Ice About Stress Urinary Incontinence in Milwaukee
3. Second Thoughts about Fluoride, Reports Scientific American
4. Mayo Clinic Proceedings Contributors Highlight Research Findings About Cardiovascular Benefits Associated With Omega-3 Fatty Acids
5. The Anatomy of Clinical Trials: Greys Season Finale Leaves Public in the Dark About the Myths and Realities
6. About 60 Clinical Studies Regarding Schering-Ploughs Oncology Compounds Will be Presented at ASCO
7. MedImmunes Motavizumab Reduced RSV Hospitalizations by 83 Percent Among High-Risk Native American, Full-Term Infants in Placebo-Controlled Phase 3 study
8. Review of Probiotic Trial Research Finds Only Bifantis(R) Able to Claim Efficacy versus Placebo for IBS Symptoms
9. New Study of Concerta(R) Showed Significant Improvement of ADHD Symptom Management in Adults Compared to Placebo
10. A Phase II, Randomized, Double Blind, Placebo-Controlled Dose-Escalating Study, Meets the Clinical Endpoints of MTR106 Tablets During the Treatment of Acute Migraine Attacks Without Aura in Females
11. New Study Results Show Asenapine More Effective Than Placebo in the Treatment of Acute Schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... , Nov. 20, 2014 /CNW Telbec/ - KLOX ... announce the following appointments: Todd ... in the newly created role of Chief Commercial Officer, ... system using topical photoconverter gel for the treatment of ... and traumatic wounds, recently approved in Europe ...
(Date:11/21/2014)... Michael DeMarco (42) erinnert sich ... Februar 2014 zugetragen hat. Seine Tochter Aly Demarco (13) ... Video - http://youtu.be/5cVoMCe0uiE „Man ... Training zu machen", erzählt Michael DeMarco . „Meine ... begeisterte Anhänger der CrossFit-Trainingsmethode. Ich war auf dem Fahrrad, ...
(Date:11/21/2014)... , Nov. 20, 2014   Coqui RadioPharmaceuticals Corp. ... first U.S. commercial producer of Molybdenum-99 (Mo-99), is proud ... INVAP to design its Medical Isotope Production ... Mo-99 is the parent isotope of Technetium-99, which is ... In 2012, Congress passed legislation making it a national ...
Breaking Medicine Technology:KLOX Technologies announces executive appointments 2KLOX Technologies announces executive appointments 3KLOX Technologies announces executive appointments 4Tochter rettet Vater durch Herz-Lungen-Wiederbelebung vor plötzlichem Herztod 2Tochter rettet Vater durch Herz-Lungen-Wiederbelebung vor plötzlichem Herztod 3Coqui RadioPharmaceuticals Inks Deal With INVAP 2
... BETHESDA, Md., May 25, 2011 Northwest Biotherapeutics (OTC.BB: ... of clinical trial sites, exceeding its projections for the ... quarter, for enrollment of new patients into the Company,s ... of DCVax® immune therapy for Glioblastoma multiforme (GBM), the ...
... 25, 2011 Executives from Medco Health Solutions, Inc. (NYSE: ... investor conferences: Timothy Wentworth, Group President, Employer and ... Strategic Decisions Conference on Wednesday, June 1 at 10 a.m. ... New York.  Richard J. Rubino, Medco,s chief financial officer, is ...
Cached Medicine Technology:Northwest Biotherapeutics Further Expands Ongoing Brain Cancer Trial 2Northwest Biotherapeutics Further Expands Ongoing Brain Cancer Trial 3Medco Executives to Present at Upcoming Investor Conferences 2
(Date:11/22/2014)... November 22, 2014 Lipitor lawsuits ( ... patients who allegedly developed Type 2 diabetes due to ... multidistrict litigation now underway in U.S. District Court, District ... court documents, the litigation will convene its next Status ... has directed Lead Counsel for Plaintiffs and Defendants to ...
(Date:11/22/2014)... Recently, UWDress.com is gratified to introduce ... . In addition, the company has also offered an ... a leading online supplier of wedding dresses, UWDress.com is ... unusual best wedding guest gowns are provided over 20 ... this new selection is famous for high quality. Therefore, ...
(Date:11/22/2014)... Sandbridge Capital, a private equity firm ... brand sector, acquired a minority stake in BackJoy ... help fund BackJoy’s global growth and accelerate the ... apparel and footwear lines. Sandbridge Capital Managing Partner ... , BackJoy is a high-growth health and wellness ...
(Date:11/22/2014)... 2014 “Greenfield Naturals” was featured on ... , which features the latest and coolest technology products ... reporter for NewsWatch, conducted the product review and shared ... of your water. , From pollution to hazardous substances ... everything is done to remove these chemicals, especially in ...
(Date:11/22/2014)... 21, 2014 (HealthDay News) -- A clinical trial of ... been halted a year early because the results show ... the disease and reduce the risk of stroke. ... 25 medical centers in the United States and Canada, ... Lung, and Blood Institute (NHLBI). Researchers compared monthly ...
Breaking Medicine News(10 mins):Health News:Lipitor Lawsuit Conference Scheduled for December, Bernstein Liebhard LLP Reports 2Health News:Lipitor Lawsuit Conference Scheduled for December, Bernstein Liebhard LLP Reports 3Health News:Best Wedding Guest dresses Introduced by UWDress.com 2Health News:Sandbridge Capital Acquires a Minority Stake in BackJoy 2Health News:Sandbridge Capital Acquires a Minority Stake in BackJoy 3Health News:An Easy Home Solution to Get Better Tasting Water was Featured on NewsWatch Television on October 30, 2014 2Health News:Sickle Cell Anemia Treatment So Successful in Kids That Trial Is Halted 2
... 4, 2008 Bayada Nurses will hold,a news conference ... and the,public about the importance of raising the Medicaid ... health care, and allow more,individuals to benefit from the ... 190,000 Pennsylvanians use home health care services each,week -- ...
... Receives National Award for Arming Oncologists, Families and ... 2008 When the,critically acclaimed A LION IN ... the film galvanized public attention for childhood cancer ... their families. Now,LION,s producers are being honored in ...
... ARBOR, Mich.---Having a husband creates an extra seven hours a ... Michigan study of a nationally representative sample of U.S. families. ... saves men from about an hour of housework a week. ... housework trends, based on 2005 time-diary data from the federally-funded ...
... Study by New York,s premier dermatologist, Dr. David J. ... first ... 4, 2008 Aesthetic Technologies,announced during the 28th Annual ... Kissimmee, Fla., the introduction of its,Parisian Peel(R) Suffusion System. ...
... Donation Will Be Made to Middle Island Man, 32, Injured ... 4, 2008 The,following was released by The SCOOTER Store:, ... New York,City patrolman and Suffolk County parks policeman, John ... Tim Bishop (NY - 1st District), Suffolk County Legislator ...
... Ohio) More than 600,000 children participate in school-sponsored ... Yet gymnastics continues to be overlooked in terms of ... injury rates of all girls sports. , A study, ... and Policy (CIRP) at The Research Institute at Nationwide ...
Cached Medicine News:Health News:Acclaimed A LION IN THE HOUSE Team Honored in Washington for Pioneering Work on Pediatric Cancer 2Health News:Acclaimed A LION IN THE HOUSE Team Honored in Washington for Pioneering Work on Pediatric Cancer 3Health News:Exactly how much housework does a husband create? 2Health News:Parisian Peel(R) Introduces Anti-Aging Suffusion System 2Health News:Parisian Peel(R) Introduces Anti-Aging Suffusion System 3
Dissecting Forceps, straight, with RF-cable, 7" (18 cm). For use with all electrosurgical generators with standard three-prong sockets....
... the art in inverted microscopy from Zeiss. ... range of ICS objectives, with innovative condensers ... an unusual scope of sophisticated documentation and ... designed. And Axiovert 200 M, fully motorized, ...
... optics and workmanship are the hallmark of ... sensitivity in mind. The top (incident) circular ... eliminating shadows while remaining cool to the ... available with 10x to 44x zoom magnification ...
... system designed for scientific microscope imaging ... cameras provides high-resolution, full-color images and ... PC via its Firewire (IEEE 1394) ... is accompanied by automatic white balance ...
Medicine Products: