Navigation Links
Controversy About Lack of Placebo Group Decline in Alzheimer's Clinical Trials
Date:7/28/2008

said. "Based on our analysis, the most reliable approach to maximize the likelihood for demonstrating efficacy is to have a placebo group size greater than 200 and to use the ADAS-cog at least four times and in English."

Scientific Review of Donepezil Trials Shows Slowing Rates of Placebo Group Decline

Professor Roy Jones, Director of RICE -- The Research Institute for the Care of Older People, based at the Royal United Hospital in Bath, England, and colleagues conducted a meta-analysis using individual patient data from randomized, double-blind, placebo-controlled studies of donepezil (Aricept) for Alzheimer's between 1990 and 1999. The work stemmed from discussions and analyses undertaken through an expert working group initiated and funded by Eisai and Pfizer, makers and marketers of donepezil.

"Our results indicate that patients with Alzheimer's entering the later clinical trials appear to be experiencing a slower rate of decline in memory and thinking processes," Jones said. "These observations are potentially important for the future design of clinical trials in people with Alzheimer's. For example, it may be necessary to conduct longer duration research studies -- more than 24 weeks -- to ensure any effects of treatment can be fully evaluated."

Data were available from 3,403 patients who participated in 13 randomized, double-blind, placebo-controlled Alzheimer trials. Data were grouped according to the year of initiation of the trials. Group 1: studies initiated in 1990-1994; Group 2: studies initiated in 1996-1999. This cut-off was associated with the timing of donepezil registration. Changes from baseline MMSE and ADAS-cog scores up to week 24 were compared between groups 1 and 2 for placebo only, and then between donepezil and placebo.

Decline on the MMSE from baseline to week 24 was significantly greater among placebo patients in group 1 (-1.28 points) compared with group 2 (-0.56 points; P = 0.024). Placebo decline on
'/>"/>

SOURCE Alzheimer's Association
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Use it or Lose it: A New Theory About Preserving Erectile Function After Prostate Surgery
2. Bonnie Blair to Break the Ice About Stress Urinary Incontinence in Milwaukee
3. Second Thoughts about Fluoride, Reports Scientific American
4. Mayo Clinic Proceedings Contributors Highlight Research Findings About Cardiovascular Benefits Associated With Omega-3 Fatty Acids
5. The Anatomy of Clinical Trials: Greys Season Finale Leaves Public in the Dark About the Myths and Realities
6. About 60 Clinical Studies Regarding Schering-Ploughs Oncology Compounds Will be Presented at ASCO
7. MedImmunes Motavizumab Reduced RSV Hospitalizations by 83 Percent Among High-Risk Native American, Full-Term Infants in Placebo-Controlled Phase 3 study
8. Review of Probiotic Trial Research Finds Only Bifantis(R) Able to Claim Efficacy versus Placebo for IBS Symptoms
9. New Study of Concerta(R) Showed Significant Improvement of ADHD Symptom Management in Adults Compared to Placebo
10. A Phase II, Randomized, Double Blind, Placebo-Controlled Dose-Escalating Study, Meets the Clinical Endpoints of MTR106 Tablets During the Treatment of Acute Migraine Attacks Without Aura in Females
11. New Study Results Show Asenapine More Effective Than Placebo in the Treatment of Acute Schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... and RALEIGH, N.C. ... Marketing Communications, LLC (CTMC), and Integrated Clinical Trial ... recruitment and retention for clinical trials announce that ... Clinical Trial Marketing Services (i-CTMS). i-CTMS will provide ... services to pharmaceutical, biotechnology and medical device companies. ...
(Date:12/15/2014)... , December 15, 2014 ... Am 19. und 20. Februar sind alle ... SAFE MEDICINE ECOSYSTEM PARTNER PROGRAMM ™ 2015 ... besuchen. Diese Tagung soll dazu ... Möglichkeit geben, die neue profitablen Unternehmensdienstleistungen, die ...
(Date:12/15/2014)... Dec. 12, 2014 Research and Markets ... "Electrocardiogram (ECG) Devices - Global Trends, Estimates and ... http://photos.prnewswire.com/prnh/20130307/600769 Global Electrocardiogram ... by 2016. The North America ... share while Europe claims approximately ...
Breaking Medicine Technology:Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 2Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 3Symposium über Aegates Ecosystem-Partner-Programm für sichere Medikamente vom 19. - 20. Februar 2015 in Amsterdam 2Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 2Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 4
... LOS ANGELES, December 2, 2011  WestPark Capital, Inc. announced ... (NYSE Amex: ISR). A total of 2,817,988 shares of common ... of common stock were sold, generating gross proceeds of ... used to fund new applications for IsoRay,s Cesium-131 technology ...
... SPRINGFIELD, Ill., Dec. 2, 2011  H. D. Smith and Adventist ...  announce a five-year agreement in which H. D. Smith will ... health system,s hospitals, home healthcare and long term care facilities. ... D. Smith will provide medical product supply chain services and ...
Cached Medicine Technology:WestPark Capital Announces $2.6 Million IsoRay Offering 2H. D. Smith and Adventist Health System Sign Prime Vendor Agreement 2H. D. Smith and Adventist Health System Sign Prime Vendor Agreement 3
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... well-known fact. Now two researchers from New Zealand are calling ... it affects the poorest who have no funds to get ... Associate Professor Tony Blakely and Dr Nick Wilson say that ... to erase smoking completely from the society since the death ...
... popular belief that drinking one or two glasses of alcohol ... alcohol has no such effect//. ,Dr Rod Jackson and ... French paradox that makes believe alcohol has its role in ... a figment of “confused research”. ,According to them, “One ...
... preventing amputations and other disease-related complications in diabetics is ... of Tamil Nadu, courtesy a hospital initiative//. ,For ... in the Community (DAPIC)" programme at Maragal Kandigai village ... a boon. DAPIC seeks to prevent diabetic foot amputations ...
... community has been arguing about the health benefits associated ... of the above argument has shown that// regular but ... obesity. ,The study was conducted amongst a ... health and nutrition survey. The participants were required to ...
... study in Chicago compares the dietary habits and increased weight ... intake of high calorie diet and employment of food as ... students//. Other factors such as selling food and organizing fund ... out to the increased body weight. About two thirds of ...
... stress has been known to interfere with several aspects of ... and endocrine levels. It has now been found// from recent ... can actually delay the wound healing process. This observation is ... level of proinflammatory proteins (molecules that play a major role ...
Cached Medicine News:Health News:Wound Healing Found To Be Slower In Couples Who Fight Often 2
PremierEdge™ Implant Knives....
Interchangeable design allows you to select a single handpiece and change tips during the procedure. Universal connector. Disassembles for easy cleaning. Tips can rotate 360 degrees to re-orient port...
Interchangeable design allows you to select a single handpiece and change tips during the procedure. Universal connector. Disassembles for easy cleaning. Tips can rotate 360 degrees to re-orient port...
Interchangeable design allows you to select a single handpiece and change tips during the procedure. Universal connector. Disassembles for easy cleaning. Tips can rotate 360 degrees to re-orient port...
Medicine Products: