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Continuous Treatment With Abbott's HUMIRA(R) Achieves Superior Long-Term Efficacy for Psoriasis Patients Compared to Interrupting Treatment
Date:9/18/2008

e relevant to use of HUMIRA in psoriasis patents," said Kim Papp, M.D., of Probity Medical Research in Waterloo, Ontario Canada.

A separate analysis of REVEAL evaluated whether specific patient characteristics would affect the efficacy of HUMIRA therapy. This second sub-group analysis found that HUMIRA effectively treats adults with psoriasis regardless of a patient's age, disease duration, whether the patient has a diagnosis of psoriatic arthritis (PsA), or if he or she has a recent history of systemic therapy, including biologic treatments. At 16 weeks, 71 percent of patients treated with HUMIRA achieved a PASI 75 response, compared with 6.5 percent of patients treated with placebo, with similar results seen among the patient subgroups.

Percentages of HUMIRA patients in subgroups who achieved PASI 75 at 16 weeks:

* Age (mean age = 44.5 years)

o 74 percent of patients 18-39 years

o 70 percent ages 40-64 years

o 61 percent age 65 and older

* Psoriasis duration (mean duration = 18.2 years)

o 68 percent diagnosed between 0.5-9.7 years

o 67 percent 9.7 - 15.9 years

o 82 percent 15.9 - 24.8 years

o 73 percent 24.8 - 65 years

* PsA diagnosis

o 70 percent of patients with a medical history of PsA

* Prior systemic treatment

o 78 percent of patients with recent history of systemic biologic

treatment (non-anti-TNF)

o 68 percent of patients with recent history of non-biologic

treatment

"These results are very reassuring for dermatologists and are important because they demonstrate that HUMIRA is a treatment option that is effective in a variety of patients with moderate to severe psoriasis," said Alan Menter, M.D., Baylor University Medical Center.

"These studies pertain to the efficacy of HUMIRA and provide further ev
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SOURCE Abbott
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