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Constellation Pharmaceuticals and The Leukemia & Lymphoma Society Partner to Develop Novel BET Inhibitor for the Treatment of Hematologic Malignancies
Date:9/20/2012

CAMBRIDGE, Mass., Sept. 20, 2012 /PRNewswire/ -- Constellation Pharmaceuticals, Inc., a leading biopharmaceutical company in the field of epigenetics, today announced that it has entered into a strategic partnership with The Leukemia & Lymphoma Society® (LLS) to advance the development of a novel BET inhibitor for the treatment of patients with hematologic malignancies. Under the terms of the agreement, LLS will provide up to $7.5 million in funding to support Constellation's small molecule BET inhibitor program through the completion of a broad Phase 1 clinical plan.  

"The Leukemia & Lymphoma Society is a leader in funding lifesaving research in hematologic malignancies," said Keith E. Dionne, Ph.D., president and CEO of Constellation Pharmaceuticals. "It is an honor to partner with a philanthropic organization that is so deeply connected with the patients who may one day benefit from our BET inhibitor therapy. We look forward to bringing a novel BET inhibitor into the clinic and to working with LLS to expand our understanding of the potential activity of BET inhibition in these diseases."

Small molecule inhibition of the bromodomain and extra-terminal – or BET – family of chromatin adaptors produces selective effects on gene expression and leads to the death of tumor cells across a broad range of hematologic malignancies and in subsets of solid tumors, making it a promising new therapeutic approach in oncology. Constellation published preclinical data in the Proceedings of the National A
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SOURCE The Leukemia & Lymphoma Society
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