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Concomitant Use of Nebulized Formoterol Fumarate and Tiotropium Provides Significant Improvement in Dyspnea, COPD Symptoms and Rescue Medication Use over Tiotropium Alone
Date:5/20/2008

s a statistical significance between the mean transitional dyspnea index scores in the Perforomist(TM)/TIO and TIO/placebo groups (2.30 and 0.16, respectively; p=0.0002). Shortness of breath, chest tightness, nighttime awakenings, and total symptom scores all improved significantly with the Perforomist(TM)/TIO treatment compared with TIO/placebo (p<0.05). Cough scores did not differ between groups. Albuterol use declined in the Perforomist(TM)/TIO group from 2.4 to1.3 puffs/day and increased in the TIO/placebo group from 2.8 to 3.4 puffs/day over six weeks; another statistically significant difference (p< 0.0001). SGRQ total scores did not change markedly from baseline or differ between groups except for the symptom domain score, which was superior in the Perforomist(TM)/TIO group compared to TIO/placebo (-6.3, p<0.04).

"DEY is very pleased with the results of this study and the benefit that patients are seeing with Perforomist(TM) Inhalation Solution," said Carolyn Myers, Ph.D., President of Dey, L.P. "We wish to thank Dr. Tashkin and the other members of the research team for their careful investigation into the clinical benefits of concomitant therapy of Perforomist and tiotropium. At DEY, we are committed to developing effective new treatments for serious and complex diseases, and with Perforomist are proud to provide physicians and patients a twice-daily COPD maintenance medication that offers the flexibility of dosing via nebulization."

For those attending ATS 2008, the presentation is available as follows:

Poster viewing: Session ID C42 COPD Pharmacotherapy I: Effects of

Bronchodilators

Tuesday, May 20, 2008, 10:45 a.m. - 12:30 p.m. EDT

Metro Toronto Convention Center; Area F: Halls A-B North Building,

Level 300

Poster # F4: Addition of Nebulized Formoterol Fumarate to Tiotropium

Treatment Relieves Dyspnea and Symptoms in COPD Patients

The research presented at ATS 2008 was supported throu
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SOURCE Dey, L.P.
Copyright©2008 PR Newswire.
All rights reserved

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