Navigation Links
Conatus Pharmaceuticals Presents Results From a Phase 2 Clinical Trial of CTS-1027 in HCV Genotype 1 Null-Responders
Date:3/31/2011

SAN DIEGO, March 31, 2011 /PRNewswire/ -- Conatus Pharmaceuticals Inc. announced today 24-week interim results from a clinical trial with CTS-1027 in combination with Peginterferon Alpha-2a (Pegasys®) and ribavirin (Copegus®) in a treatment experienced, hepatitis C virus (HCV) null-responder patient population.  Null-responder patients are the most difficult to treat patient population and are clinically defined as those patients failing to achieve an early virologic response (EVR) when undergoing treatment with the current standard of care (SOC; pegylated interferon and ribavirin).  EVR is defined as at least a 2 log decline in HCV-RNA by week 12 of SOC treatment.  The CTS-1027-04 clinical trial enrolled 67 HCV genotype 1 null-responder patients.  The clinical trial is a single arm and open label design with sustained viral response (SVR; no detectable virus 24 weeks after the end of treatment) as its primary end point.  At week 12, 51% (31/61) of patients receiving 15 mg twice a day of CTS-1027 in addition to standard doses of Pegasys® and Copegus® achieved an EVR on a per protocol (PP) basis.  HCV-RNA was below quantifiable limit (BQL) in 5 patients (8.2%, PP) at week 12 and increased to 17 patients (34%, 17/50, PP) at week 24.  This clinical trial is ongoing and final SVR results are expected in 2011.

Data from the CTS-1027-04 clinical trial were presented at the 46th annual meeting of the European Association for the Study of the Liver (EASL) held in Berlin, Germany, as Abstract 468.  The full abstract is available at www.conatuspharma.com.

Consistent with expectations, the majority of patients tested for genetic analysis of IL-28B (95%, 58/61) carried the CT or TT allelic variant.  Patients possessing these genetic variants are predicted to be less responsive to the antiviral actions of interferon.

"Most other approaches
'/>"/>

SOURCE Conatus Pharmaceuticals Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Conatus Pharmaceuticals Reports Positive Results of CTS-1027 in Multiple Preclinical Studies of Liver Disease
2. Conatus Pharmaceuticals Initiates a Second Phase 2 Clinical Trial for the Treatment of Hepatitis
3. Conatus Pharmaceuticals to Present at the Montgomery Healthcare Conference
4. Conatus Pharmaceuticals Initiates Phase II Clinical Trial in Combination With Pegylated Interferon and Ribavirin for the Treatment of Hepatitis C Virus (HCV)
5. Conatus Pharmaceuticals Acquires Pfizers Idun Subsidiary
6. Conatus Pharmaceuticals Completes $20 Million Series B Private Placement Financing
7. Conatus Pharmaceuticals Initiates Confirmatory Phase 2 Clinical Trial of CTS-1027 for the Treatment of Hepatitis C Virus (HCV)
8. Conatus Pharmaceuticals Will Display HCV Clinical Trial Data at the International Liver Congress™ (EASL) in March
9. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
10. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
11. Solvay Pharmaceuticals, Inc. and Wyeth Pharmaceuticals Announce Receipt of an FDA Action Letter for Bifeprunox, an Investigational Treatment for Schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... Inc. (NasdaqGS: ABAX ), a medical products ... results for the first fiscal quarter ended June 30, ... of $47.5 million, up 10% over last year,s comparable ... over last year,s comparable quarter. Revenues highlights: ... 20% over last year,s comparable quarter. , Veterinary ...
(Date:7/24/2014)... , July 24, 2014  IRIDEX Corporation (NASDAQ: ... its second quarter 2014 financial results after the market ... conjunction with the release, the Company will host a ... p.m. Eastern Time on Thursday, July 31, ... and other business developments. Interested parties may ...
(Date:7/24/2014)... 24, 2014 Omnicell, Inc. (NASDAQ: ... and supply management solutions and analytics software for ... 31, to discuss the Company,s Second Quarter 2014 ... 2014 earnings conference call and webcastWhen: , ... Lipps, chairman, president and chief executive officer ...
Breaking Medicine Technology:Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 2Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 3Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 4Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 5Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 6Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 7Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 8Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 9Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 10Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 11Omnicell to Release Second Quarter 2014 Earnings Results on July 31 2
... CHICAGO, Nov. 29, 2011  In a new study presented today ... America (RSNA), growth hormone replacement for six months was found ... "This is the first time that the effects of growth ... study,s lead author, Miriam A. Bredella, M.D., a radiologist at ...
... Nov. 29, 2011  Newly developed computer software combined with magnetic ... assess a woman,s potential for a difficult childbirth. Results of ... the annual meeting of the Radiological Society of North America ... and not much wider than a fetus,s head, a baby ...
Cached Medicine Technology:Growth Hormone Increases Bone Formation in Obese Women 2Virtual Childbirth Simulator Improves Safety of High-Risk Deliveries 2Virtual Childbirth Simulator Improves Safety of High-Risk Deliveries 3
(Date:7/25/2014)... 25, 2014 Yisrayl Hawkins, Pastor and Overseer ... on his blog explaining why so many prayers are going ... , In the article, Yisrayl gives many examples around ... the results. For example, in one case, in the small ... grounds to pray for rain; ironically, they received a massive ...
(Date:7/25/2014)... July 25, 2014 iTanSmart is a ... iPads. The app provides a tailored approach to eliminating ... dangerous sunburns and skin damage. In his review, Eaton ... and capabilities of iTanSmart. , Eaton begins his ... as a ‘better organized’ and ‘great alternative’ to its ...
(Date:7/25/2014)... According to the Liver Cirrhosis ... Vkool.com, this is a comprehensive guide that provides ... safe remedies for liver cirrhosis . This ...     Chapter 1: Liver Cirrhosis Bible & ... About Liver Basics ,     Chapter 3: Getting ...
(Date:7/25/2014)... DC (PRWEB) July 25, 2014 At ... Washington DC July 19, 17 participating developmentally-disabled teens and ... fun, even if off-road bicycling, canoeing and hiking can ... national non-profit at the scenic Chesapeake and Ohio ... of participating athletes both disabled and able-bodied. Under slightly ...
(Date:7/24/2014)... 2014 Dr. Henry H. Ting, a ... has been appointed senior vice president and chief quality ... his new role, he will oversee the hospital's clinical ... successfully led quality initiatives and interprofessional teams at the ... for the Door-to-Balloon Alliance, a collaboration of more than ...
Breaking Medicine News(10 mins):Health News:Yisrayl Hawkins Says Prayers for Rain Result in Violent Hail Because Prayers Are Not Being Heard in New Post 2Health News:Yisrayl Hawkins Says Prayers for Rain Result in Violent Hail Because Prayers Are Not Being Heard in New Post 3Health News:iTanSmart® Suntan App by UV Technologies, LLC Gets a ‘Big Thumbs Up’ from New York Times App Smart Columnist, Kit Eaton 2Health News:iTanSmart® Suntan App by UV Technologies, LLC Gets a ‘Big Thumbs Up’ from New York Times App Smart Columnist, Kit Eaton 3Health News:Liver Cirrhosis Bible & Ezra Protocol Review Exposes Debra Elkin's Liver Cirrhosis Treatment Guide – Vkool - Better Information, Better Lives 2Health News:Liver Cirrhosis Bible & Ezra Protocol Review Exposes Debra Elkin's Liver Cirrhosis Treatment Guide – Vkool - Better Information, Better Lives 3Health News:DC Adventure Team Challenge Thrills Developmentally-Disabled Participants 2Health News:DC Adventure Team Challenge Thrills Developmentally-Disabled Participants 3Health News:NewYork-Presbyterian Hospital Names New Senior Vice President for Quality and Patient Safety 2Health News:NewYork-Presbyterian Hospital Names New Senior Vice President for Quality and Patient Safety 3
... Record Revenue and Earnings per Share for the ... leading,provider of clinical software, connectivity and information solutions ... for the three,months and year ended December 31, ... revenue for the three months ended December 31, ...
... wife,of Red Sox star Dustin Pedroia, recently joined the ... be speaking out about the,dangers of tanning. She should ... a,year after her last dance at her senior prom ... http://www.newscom.com/cgi-bin/prnh/20080213/DC14158 ), "I really had no idea ...
... Leadership ... Team, Safeguards, METAIRIE, La., ... and dental practices,worldwide, today lauded the Securities and Exchange Commission,s (SEC) ... of OCA, Inc. (OCA). In conjunction with the filing of the,complaint, ...
... 13, 2008 -- The first genome-wide search for genes ... social creatures -- the amoebae Dictyostelium discoideum -- have ... behavior. , The study by scientists at Rice University ... this week by the journal Nature. It marks one ...
... ATLANTA, Feb. 13 Vendormate, Inc. announced ... America (CHCA) to make,Vendormate VISION(TM), its vendor ... children,s hospitals. Vendormate VISION(TM) is,used by leading ... better manage,the increasingly complex requirements of government-mandated ...
... Feb. 13 Quintiles,Transnational Corp. today announced that ... the College of American Pathologists (CAP)., The ... in the first,quarter of 2007. The facility has ... analytical capabilities to a growing test menu., ...
Cached Medicine News:Health News:Allscripts Reports Fourth Quarter 2007 Results 2Health News:Allscripts Reports Fourth Quarter 2007 Results 3Health News:Allscripts Reports Fourth Quarter 2007 Results 4Health News:Allscripts Reports Fourth Quarter 2007 Results 5Health News:Allscripts Reports Fourth Quarter 2007 Results 6Health News:Allscripts Reports Fourth Quarter 2007 Results 7Health News:Allscripts Reports Fourth Quarter 2007 Results 8Health News:Allscripts Reports Fourth Quarter 2007 Results 9Health News:Allscripts Reports Fourth Quarter 2007 Results 10Health News:Kelli Pedroia, Wife of Red Sox Dustin Pedroia, Joins Melanoma Foundation of New England to Warn About Tanning for the Prom 2Health News:OrthoSynetics(TM) Applauds SEC Suit Against Former Company Management 2Health News:Microbial 'cheaters' help scientists ID 'social' genes 2Health News:Microbial 'cheaters' help scientists ID 'social' genes 3Health News:Vendormate and CHCA Finalize Agreement to Offer Compliance and Security Solutions to Children's Hospitals 2Health News:Quintiles Central Laboratory in India Receives CAP Certification 2
Gillies (Converse) Skin Hook, small hook size....
The Accuref 8001 allows you to measure much smaller pupils than conventional units and 3 step Target light adjuster ensures accurate results....
Sterile free isotonic balanced salt solution...
Sterile Silicone Oil for Intraocular Application....
Medicine Products: