Navigation Links
Conatus Pharmaceuticals Presents Results From a Phase 2 Clinical Trial of CTS-1027 in HCV Genotype 1 Null-Responders
Date:3/31/2011

SAN DIEGO, March 31, 2011 /PRNewswire/ -- Conatus Pharmaceuticals Inc. announced today 24-week interim results from a clinical trial with CTS-1027 in combination with Peginterferon Alpha-2a (Pegasys®) and ribavirin (Copegus®) in a treatment experienced, hepatitis C virus (HCV) null-responder patient population.  Null-responder patients are the most difficult to treat patient population and are clinically defined as those patients failing to achieve an early virologic response (EVR) when undergoing treatment with the current standard of care (SOC; pegylated interferon and ribavirin).  EVR is defined as at least a 2 log decline in HCV-RNA by week 12 of SOC treatment.  The CTS-1027-04 clinical trial enrolled 67 HCV genotype 1 null-responder patients.  The clinical trial is a single arm and open label design with sustained viral response (SVR; no detectable virus 24 weeks after the end of treatment) as its primary end point.  At week 12, 51% (31/61) of patients receiving 15 mg twice a day of CTS-1027 in addition to standard doses of Pegasys® and Copegus® achieved an EVR on a per protocol (PP) basis.  HCV-RNA was below quantifiable limit (BQL) in 5 patients (8.2%, PP) at week 12 and increased to 17 patients (34%, 17/50, PP) at week 24.  This clinical trial is ongoing and final SVR results are expected in 2011.

Data from the CTS-1027-04 clinical trial were presented at the 46th annual meeting of the European Association for the Study of the Liver (EASL) held in Berlin, Germany, as Abstract 468.  The full abstract is available at www.conatuspharma.com.

Consistent with expectations, the majority of patients tested for genetic analysis of IL-28B (95%, 58/61) carried the CT or TT allelic variant.  Patients possessing these genetic variants are predicted to be less responsive to the antiviral actions of interferon.

"Most other approaches
'/>"/>

SOURCE Conatus Pharmaceuticals Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Conatus Pharmaceuticals Reports Positive Results of CTS-1027 in Multiple Preclinical Studies of Liver Disease
2. Conatus Pharmaceuticals Initiates a Second Phase 2 Clinical Trial for the Treatment of Hepatitis
3. Conatus Pharmaceuticals to Present at the Montgomery Healthcare Conference
4. Conatus Pharmaceuticals Initiates Phase II Clinical Trial in Combination With Pegylated Interferon and Ribavirin for the Treatment of Hepatitis C Virus (HCV)
5. Conatus Pharmaceuticals Acquires Pfizers Idun Subsidiary
6. Conatus Pharmaceuticals Completes $20 Million Series B Private Placement Financing
7. Conatus Pharmaceuticals Initiates Confirmatory Phase 2 Clinical Trial of CTS-1027 for the Treatment of Hepatitis C Virus (HCV)
8. Conatus Pharmaceuticals Will Display HCV Clinical Trial Data at the International Liver Congress™ (EASL) in March
9. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
10. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
11. Solvay Pharmaceuticals, Inc. and Wyeth Pharmaceuticals Announce Receipt of an FDA Action Letter for Bifeprunox, an Investigational Treatment for Schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2015)... April 30, 2015 /PRNewswire/ - Pivotal Therapeutics Inc. ... with a focus on Omega-3 therapies for cardiovascular ... highlights and financial results for the fiscal year ... herein are in Canadian dollars unless otherwise stated. ... significant, with the right strategic partners and additional ...
(Date:4/30/2015)... -- Omnicell, Inc. (NASDAQ: OMCL ), a leading provider ... today announced results for its first quarter ended March ... first quarter of 2015 was $116.2 million, up $14.5 ... and down $5.3 million or 4.4% from the fourth ... income as reported in accordance with U.S. generally accepted ...
(Date:4/30/2015)... MOUNTAIN VIEW, Calif. , April 30, 2015 /PRNewswire/ ... it will release its first quarter 2015 financial results ... 2015.   In conjunction with the release, the Company ... at 5:00 p.m. Eastern Time on ... of the quarter and other business developments. ...
Breaking Medicine Technology:Pivotal Therapeutics Announces 2014 Financial Results 2Pivotal Therapeutics Announces 2014 Financial Results 3Pivotal Therapeutics Announces 2014 Financial Results 4Pivotal Therapeutics Announces 2014 Financial Results 5Pivotal Therapeutics Announces 2014 Financial Results 6Omnicell Announces First Quarter 2015 Results 2Omnicell Announces First Quarter 2015 Results 3Omnicell Announces First Quarter 2015 Results 4Omnicell Announces First Quarter 2015 Results 5Omnicell Announces First Quarter 2015 Results 6Omnicell Announces First Quarter 2015 Results 7Omnicell Announces First Quarter 2015 Results 8Omnicell Announces First Quarter 2015 Results 9Omnicell Announces First Quarter 2015 Results 10Omnicell Announces First Quarter 2015 Results 11Omnicell Announces First Quarter 2015 Results 12Omnicell Announces First Quarter 2015 Results 13Omnicell Announces First Quarter 2015 Results 14Omnicell Announces First Quarter 2015 Results 15Omnicell Announces First Quarter 2015 Results 16Omnicell Announces First Quarter 2015 Results 17Omnicell Announces First Quarter 2015 Results 18Omnicell Announces First Quarter 2015 Results 19Omnicell Announces First Quarter 2015 Results 20Omnicell Announces First Quarter 2015 Results 21Omnicell Announces First Quarter 2015 Results 22Omnicell Announces First Quarter 2015 Results 23Omnicell Announces First Quarter 2015 Results 24Omnicell Announces First Quarter 2015 Results 25Omnicell Announces First Quarter 2015 Results 26Omnicell Announces First Quarter 2015 Results 27IRIDEX Announces First Quarter 2015 Conference Call and Release Date 2
(Date:5/3/2015)... 2015 SpineFrontier, a Less Exposure Surgery ... to produce and market their new sacroiliac joint fusion ... in outpatient settings and is compatible with both lateral ... has been extensively researched and refined by SpineFrontier, the ... this approach in conjunction with a sacroiliac joint fusion ...
(Date:5/2/2015)... 02, 2015 Ticket Down has secured additional ... the long awaited event today, Saturday, May 2nd at the ... fans will be able to secure tickets for both the ... that boxing fans have wanted for more than five years ... “Money” Mayweather will step inside the ring to fight Manny ...
(Date:5/2/2015)... May 02, 2015 It’s a pattern ... natural disaster strikes anywhere on this planet, cyber scammers ... sympathy and compassion for their own personal gain. ... Emergency Readiness Team) issued an alert titled “Nepal ... email scams citing the earthquake in Nepal. The scam ...
(Date:5/2/2015)... IL (PRWEB) May 02, 2015 Kare Visits ... provide support for busy caregivers. Kare Visits offers relief ... and assisted living facilities. According to the Caregiver ... spend an average of 20 hours a week caring for ... of the cost to hire a nurse, a caregiver is ...
(Date:5/1/2015)... Frisco, Texas (PRWEB) May 02, 2015 ... Frisco, Texas, is proud to announce the addition of ... Jen Widerstrom is a life long athlete, growing up ... fitness passion after college by becoming a personal trainer ... since been the face of several TV shows highlighting ...
Breaking Medicine News(10 mins):Health News:Cheap Floyd Mayweather vs. Manny Pacquiao Tickets: Ticket Down Has Last Minute Tickets for Mayweather vs. Pacquiao at the MGM Grand Garden Arena in Las Vegas 2Health News:Cheap Floyd Mayweather vs. Manny Pacquiao Tickets: Ticket Down Has Last Minute Tickets for Mayweather vs. Pacquiao at the MGM Grand Garden Arena in Las Vegas 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 4Health News:Chicagoan Seeks to Transform Industry by Launching an Innovative Elderly Care Solution 2Health News:IDLife LLC Announces New Partnership with Fitness Celebrity, Jen Widerstrom 2
... oil spill along the United States Gulf Coast poses health ... communities, according to a new commentary by UCSF researchers who ... to look into health problems caused by the oil spill. ... of the risk factors, coastal air quality, is improving now ...
... dependent a man is on his female partner, the more ... to be presented at the 105th Annual Meeting of the ... to have the opposite effect: the more dependent they are ... engage in infidelity," said Christin Munsch, a sociology Ph.D. candidate ...
... BOSTON, Mass. (August 12, 2010) Once thought to be a ... cause of death and disability,in poorer countries. Almost two-thirds of ... and middle-income countries. A paper to be published online ... the international community must now discard the notion that cancer ...
... Facial pain. Nasal congestion. Postnasal drip. Fatigue. ... tissue in the nasal and sinus cavity. The illness strikes ... top five reasons patients visit their primary care doctor. Treating ... if the cause is viral or bacterial. Unfortunately little ...
... Gardner HealthDay Reporter , WEDNESDAY, Aug. 11 ... deep brain stimulation appeared to improve memory slightly in ... caution that the findings are very preliminary and that ... study. However, test results and brain imaging suggest that ...
... HealthDay Reporter , FRIDAY, Aug. 13 (HealthDay ... take acetaminophen, best known as Tylenol, were more than ... never take the over-the-counter pain and fever reducer, new ... an increased chance of eczema and rhinoconjunctivitis, or allergic ...
Cached Medicine News:Health News:Health impact of Gulf Coast oil spill hazardous but improving 2Health News:Health impact of Gulf Coast oil spill hazardous but improving 3Health News:Men more likely to cheat if they are economically dependent on their female partners 2Health News:Global health leaders advocate for expanding cancer care in developing countries 2Health News:Global health leaders advocate for expanding cancer care in developing countries 3Health News:Primary care doctors get little information about chronic sinusitis 2Health News:Deep Brain Stimulation Studied for Alzheimer's 2Health News:Deep Brain Stimulation Studied for Alzheimer's 3Health News:Tylenol Use Linked to Asthma, Other Allergies in Teens 2Health News:Tylenol Use Linked to Asthma, Other Allergies in Teens 3Health News:Tylenol Use Linked to Asthma, Other Allergies in Teens 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: