Navigation Links
Complete Study Results Comparing CTI's OPAXIO(TM) With Gemcitabine or Vinorelbine in Performance Status (PS 2) NSCLC Patients Published in Journal of Thoracic Oncology
Date:7/6/2008

atients with advanced NSCLC were randomized to the comparator arm; 191 were randomized to the OPAXIO arm with a dosage of 175 mg/m^2, and 96 were randomized to the OPAXIO arm at a dosage of 235 mg/m^2. The OPAXIO dose was reduced to 175 mg/m^2 after 96 patients had been treated, because the Data Monitoring Committee noted an increase in deaths associated with neutropenia in patients who had received the 235 mg/m^2 dosage. The following data refers to those patients treated at the OPAXIO dose of 175 mg/m^2. The median number of cycles administered was 4, with a median of 3.5 in the control arm. A total of 754 cycles of OPAXIO were administered, and 652 cycles were administered in the comparator arm. More patients in the OPAXIO arm received 6 cycles of treatment (38 percent versus 23 percent; p = 0.002). Progressive disease was the most common reason for not completing 6 cycles (55 percent in the OPAXIO arm and 59 percent in the comparator arm). Fewer OPAXIO patients (12 percent) discontinued treatment as a result of adverse events, compared to 17 percent of patients in the control arm. Survival, time to progression (TTP), and response rates were similar in both arms. Median overall survival was 7.3 months in the OPAXIO arm and 6.6 months in the control arm. The estimated 1-year survival rate was the same in both arms (26 percent), and the approximate 2-year survival rate was numerically higher in the OPAXIO arm (15 percent) than the comparator arm (10 percent). There was a lower requirement for red blood cell transfusions (p = 0.001), erythropoietin use (p = 0.014), myeloid growth factors (p = 0.032), and new narcotic analgesics (p = 0.034) in the OPAXIO arm when compared to the control arm. No significant differences were evident in quality of life based on FACT-LCS evaluations between the two arms. OPAXIO patients experienced fewer hematologic (p <0.001) and gastrointestinal (p = 0.004) adverse events. Neuropathy occurred more frequently in the OPAXIO arm compared
'/>"/>
SOURCE Cell Therapeutics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Isolagen Completes Pivotal Efficacy Portion of Phase III Studies of Isolagen Therapy(TM) for Wrinkles
2. Genzyme and Isis Complete Licensing of Mipomersen
3. Neurocrine Biosciences Completes Petal Study Treatment Phase for Endometriosis
4. Metabolex Completes Patient Enrollment in Phase 2 Trial of MBX-8025 for Treatment of Dyslipidemia
5. ChemoCentryx Completes Enrollment of PROTECT-1, a Phase II/III Clinical Trial of CCR9 Antagonist CCX282-B (Traficet-EN(TM)) in Crohns Disease
6. Pharmaxis Long-Term Safety Study of Bronchitol Completes
7. Alexza Completes Enrollment in Phase 3 Clinical Trial with AZ-004 (Staccato(R) Loxapine) for Acute Agitation
8. Nephros Completes Pivotal U.S. Clinical Trial for its Hemodiafiltration Products
9. Phase 1/2 Trial of Motexafin Gadolinium Plus Antibody Targeted Radiation Therapy Demonstrates High Complete Response Rate in Patients With Non-Hodgkins Lymphoma
10. Arno Therapeutics, Inc. Completes $18 Million Financing and Reverse Merger with Laurier International, Inc.
11. Jazz Pharmaceuticals, Inc. Completes Enrollment in First of Two Phase III Clinical Trials of Sodium Oxybate to Treat Fibromyalgia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... York , September 2, 2014 ... published by Transparency Market Research "Latin America Home ... Devices, Therapeutic Home Healthcare Devices, Mobility Assist Devices ... Telemedicine, Respiratory Therapy, Infusion Therapy and Unskilled Home ... Trends and Forecast, 2014 - 2020" the Latin ...
(Date:9/2/2014)... Spanje, September 2, 2014 ... AF Registry bij het ESC CONGRESS 2014 ... patiënten met risico op beroerte in de ... Gegevens van bijna 12.500 patiënten ingeschreven in ... Fibrillation (GARFIELD-AF), een innovatief, onafhankelijk initiatief op ...
(Date:9/2/2014)... 2, 2014 , ... provide insight into treatment and outcomes of patients ... --   Data from nearly 12,500 ... the FIELD-Atrial Fibrillation (GARFIELD-AF), an innovative, independent academic ... for atrial fibrillation (AF) patients remain sub-optimal despite ...
Breaking Medicine Technology:Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 2Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 3Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 4Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 5Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 6Gegevens uit wereldwijde atriumfibrillatieregister tonen aan dat antistollingsmiddelen niet optimaal worden gebruikt ter preventie van beroerte 2Gegevens uit wereldwijde atriumfibrillatieregister tonen aan dat antistollingsmiddelen niet optimaal worden gebruikt ter preventie van beroerte 3Gegevens uit wereldwijde atriumfibrillatieregister tonen aan dat antistollingsmiddelen niet optimaal worden gebruikt ter preventie van beroerte 4Gegevens uit wereldwijde atriumfibrillatieregister tonen aan dat antistollingsmiddelen niet optimaal worden gebruikt ter preventie van beroerte 5Gegevens uit wereldwijde atriumfibrillatieregister tonen aan dat antistollingsmiddelen niet optimaal worden gebruikt ter preventie van beroerte 6Gegevens uit wereldwijde atriumfibrillatieregister tonen aan dat antistollingsmiddelen niet optimaal worden gebruikt ter preventie van beroerte 7Gegevens uit wereldwijde atriumfibrillatieregister tonen aan dat antistollingsmiddelen niet optimaal worden gebruikt ter preventie van beroerte 8Gegevens uit wereldwijde atriumfibrillatieregister tonen aan dat antistollingsmiddelen niet optimaal worden gebruikt ter preventie van beroerte 9Gegevens uit wereldwijde atriumfibrillatieregister tonen aan dat antistollingsmiddelen niet optimaal worden gebruikt ter preventie van beroerte 10Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 2Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 3Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 4Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 5Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 6Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 7Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 8Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 9
... Inc. (Nasdaq: REGN ) will webcast its ... 15, 2011.  The presentation is scheduled for 2:10 p.m. ... Company,s web site, www.regeneron.com , on the Investor ... be available after the live webcast through March 17, ...
... Pervasis Therapeutics announced today that the U.S. Food and ... for Vascugel® for the prevention of hemodialysis access failure ... Vascugel, a novel endothelial cell-based therapy and Pervasis, ... response following surgical interventions to create vascular access points ...
Cached Medicine Technology:Pervasis Receives FDA Fast Track Status for Vascugel® to Prevent Arteriovenous Access Failure in Patients Undergoing Hemodialysis 2Pervasis Receives FDA Fast Track Status for Vascugel® to Prevent Arteriovenous Access Failure in Patients Undergoing Hemodialysis 3Pervasis Receives FDA Fast Track Status for Vascugel® to Prevent Arteriovenous Access Failure in Patients Undergoing Hemodialysis 4Pervasis Receives FDA Fast Track Status for Vascugel® to Prevent Arteriovenous Access Failure in Patients Undergoing Hemodialysis 5
(Date:9/2/2014)... 02, 2014 Becker's Healthcare is ... Educational Program on October 23-25, 2014 at the ... Meeting - The Business and Operations of ASCs ... high-quality continuing education, networking events, and an exhibit ... , Outstanding educational offerings throughout the three-day event, ...
(Date:9/2/2014)... Today, Therapy Changes released ... Me?” The guide outlines common questions an individual may ... to common types of groups an individual can attend. ... the interventions of the therapist, but also from observing ... members,” says Rochelle Perper, Ph.D. and founder of Therapy ...
(Date:9/2/2014)... Washington, DC (PRWEB) September 02, 2014 TCG, ... named by Inc. 5000 as one of the fastest-growing companies ... the eighth time total. TCG was previously recognized in 2013, ... 2001. , TCG’s revenue has grown 86% from 2010 to ... of the fastest growing businesses in America - up 635 ...
(Date:9/2/2014)... Columbia, SC (PRWEB) September 02, 2014 The ... an outreach fair and public town hall meeting for Veterans ... be available at the outreach fair to provide Veterans with ... B. McMurry. “The town hall will provide a forum where ... our VA programs.” , The outreach fair will be held ...
(Date:9/2/2014)... in California, the percentage undergoing a double mastectomy increased ... not associated with a lower risk of death than ... the September 3 issue of JAMA . The ... one breast was associated with a higher risk of ... , Randomized trials have demonstrated similar survival for patients ...
Breaking Medicine News(10 mins):Health News:Becker's Healthcare Announces Ambulatory Surgery Center Educational Program 2Health News:Becker's Healthcare Announces Ambulatory Surgery Center Educational Program 3Health News:TCG One of the Fastest-Growing Companies in America – for the Eighth Time! 2Health News:Increase seen in use of double mastectomy 2Health News:Increase seen in use of double mastectomy 3
... , , LAS VEGAS, Aug. ... America (HCA), dozens of registered nurses from HCA facilities across the ... of nurses from the company,s MountainView Hospital, after management refused to ... Nurses Organizing Committee (CNA/NNOC). , , MountainView ...
... , , , ... The Simmons firm, a leading national law firm in the fight ... one of the foremost trial attorneys in the country, has joined ... has tried dozens of asbestos cancer cases since the late 1970s. ...
... uncovers big jump between 1999-2006, especially among older females ... involving more than 6,000 American women suggests that blood ... big rise noted over the past decade. , Using ... Prevention,s National Health and Nutrition Examination Survey (NHANES), a ...
... , , FARMINGTON HILLS, Mich., ... (DCC) with a group purchasing contract to provide RFID Asset ... alliance is the largest in the country, comprised of more ... over $31 billion in annual purchasing power. , ...
... VERONA, N.Y., Aug. 24 , , , WHAT: ... Atunyote Golf Club course in Verona, N.Y., today in a skins, ... Foundation., ... top-ranked golfer, Tiger Woods. Looking to fend off Woods will, ...
... , , ATLANTA, Aug. 24 ... the nation,s largest direct retailer of foot and lower body ... 20th Anniversary. Since 1989, the company has upheld two consumer ... comfort, and providing expert customer information and service. FootSmart offers ...
Cached Medicine News:Health News:Nurses from HCA Hospitals Nationwide Rally in Support of MountainView RNs Today 2Health News:Decorated Trial Attorney Conard Metcalf Joins Simmons Firm as 'Of Counsel' 2Health News:Decorated Trial Attorney Conard Metcalf Joins Simmons Firm as 'Of Counsel' 3Health News:Blood Mercury Levels Rising Among U.S. Women 2Health News:Tiger Woods, Camilo Villegas, Mike Weir and Notah Begay III Play at 2009 Notah Begay III Foundation Challenge Monday, August 24 2Health News:Benchmark Brands Celebrates 20th Anniversary 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: